Ptges prostaglandin E synthase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ptgesprovided by RGD
Official Full Name: prostaglandin E synthaseprovided by RGD
Primary source: RGD:62076
See related: EnsemblRapid:ENSRNOG00000076770 AllianceGenome:RGD:62076
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pges; mPGES-1
Summary: Enables prostaglandin-D synthase activity and prostaglandin-E synthase activity. Involved in several processes, including prostaglandin biosynthetic process; response to lipopolysaccharide; and response to retinoic acid. Located in perinuclear region of cytoplasm. Biomarker of Barrett's esophagus; ischemia; papilloma; peptic esophagitis; and transitional cell carcinoma. Orthologous to human PTGES (prostaglandin E synthase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 58.7), Thymus (RPKM 32.7) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3p12

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (34575643..34586987, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (14177892..14189236, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (9727408..9738752, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PTGES is involved in myofibroblast differentiation via HIF-1alpha-dependent glycolysis pathway.
Title: PTGES is involved in myofibroblast differentiation via HIF-1α-dependent glycolysis pathway.
In conclusion, microsomal PGES-1 plays a critical role in the continuous suppression of motor function in the post-bowel obstruction state.
Title: Microsomal Prostaglandin E Synthase-1 Plays a Critical Role in Long-term Motility Dysfunction after Bowel Obstruction.
Suggest pivotal role of COX-2-mPGES-1-PGE2 axis in vascular calcification. Inhibition of COX-2 or mPGES-1 may increase the risk of calcification and subsequent adverse cardiovascular events during chronic renal failure.
Title: Microsomal Prostaglandin E Synthase-1-Derived PGE2 Inhibits Vascular Smooth Muscle Cell Calcification.
Using metabolic profiling and exploratory rat toxicity studies, a new and active mPGES-1 inhibitor with improved margins to chemically induced kidney toxicity in rats has been identified.
Title: Amide hydrolysis of a novel chemical series of microsomal prostaglandin E synthase-1 inhibitors induces kidney toxicity in the rat.
Cyclooxygenase-2, not microsomal prostaglandin E synthase-1, is the mechanism for interleukin-1beta-induced prostaglandin E2 production and inhibition of insulin secretion in pancreatic islets
Title: Cyclooxygenase-2, not microsomal prostaglandin E synthase-1, is the mechanism for interleukin-1β-induced prostaglandin E2 production and inhibition of insulin secretion in pancreatic islets.
Suggest that COX-2 and PGES, and in turn PGE(2), might play important roles in follicular cell proliferation but do not affect tumor induction in N-bis(2-hydroxypropyl)nitrosamine-induced thyroid carcinogenesis model.
Title: Prostaglandin synthases influence thyroid follicular cell proliferation but not carcinogenesis in rats initiated with N-bis(2-hydroxypropyl)nitrosamine.
study has shown that circulating IL-6 can directly induce mPGES-1 linked to STAT3-activation in the brain but not peripheral tissues of rats during localised peripheral inflammation
Title: Circulating IL-6 contributes to peripheral LPS-induced mPGES-1 expression in the rat brain.
Minocycline (3-100 microM) inhibits microsomal prostaglandin E synthase.
Title: Minocycline reduces prostaglandin E synthase expression and 8-isoprostane formation in LPS-activated primary rat microglia.
initial inflammation prepares the spinal cord for a negative feedback regulation by mPGES-1-derived PGE(2) followed by EP2 activation, which limits the synthesis of inflammatory mediators during chronic inflammation.
Title: Anti-inflammatory role of microsomal prostaglandin E synthase-1 in a model of neuroinflammation.
Microsomal prostaglandin E synthase-1-derived PGE(2) mediates lithium-induced polyuria likely via inhibition of aquaporin-2 and Na-K-2Cl cotransporter expression.
Title: Mice lacking mPGES-1 are resistant to lithium-induced polyuria.

Submit: New GeneRIF Correction See all GeneRIFs (18)

General gene information

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Markers

AU048497 (e-PCR)
- UniSTS:144947

AU049847 (e-PCR)
- UniSTS:146293

D3Chm40 (e-PCR)
- UniSTS:265371

D3Chm41 (e-PCR)
- UniSTS:265400

RH129128 (e-PCR)
- UniSTS:212436

RH134815 (e-PCR)
- UniSTS:218093

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables glutathione binding	ISO Inferred from Sequence Orthology more info
enables glutathione peroxidase activity	ISO Inferred from Sequence Orthology more info
enables glutathione peroxidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables glutathione transferase activity	ISO Inferred from Sequence Orthology more info
enables glutathione transferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables prostaglandin-D synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables prostaglandin-D synthase activity	ISO Inferred from Sequence Orthology more info
enables prostaglandin-E synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables prostaglandin-E synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables prostaglandin-E synthase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
involved_in chronic inflammatory response	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of prostaglandin secretion	ISO Inferred from Sequence Orthology more info
involved_in prostaglandin biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in prostaglandin biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in prostaglandin biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in prostaglandin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in prostaglandin biosynthetic process	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within prostaglandin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of fever generation	ISO Inferred from Sequence Orthology more info
involved_in regulation of fever generation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in regulation of inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to calcium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cytokine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to retinoic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of pain	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope lumen	ISO Inferred from Sequence Orthology more info
NOT located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: prostaglandin E synthase

Names: glutathione peroxidase PTGES; glutathione transferase PTGES; inducible prostaglandin E synthase; microsomal prostaglandin E synthase 1

NP_067594.1

EC 2.5.1.18

EC 5.3.99.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.