U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Hrk harakiri, BCL2 interacting protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117271, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Hrkprovided by RGD
    Official Full Name
    harakiri, BCL2 interacting proteinprovided by RGD
    Primary source
    RGD:70549
    See related
    EnsemblRapid:ENSRNOG00000079458 AllianceGenome:RGD:70549
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dp5; Bid3
    Summary
    Involved in cellular response to potassium ion starvation and positive regulation of neuron apoptotic process. Predicted to be located in membrane. Predicted to be active in mitochondrion. Orthologous to human HRK (harakiri, BCL2 interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Note: NM_057130.4 is based on transcript and protein alignment data, and may not be a true representation of the structure of GeneID 117271 due to the incomplete nature of the assembly in this region of the genome. [10 Oct 2014]
    Expression
    Biased expression in Brain (RPKM 47.4) and Adrenal (RPKM 3.3) See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Hrk in Genome Data Viewer
    Location:
    12q16
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (44048402..44070561, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (38387484..38409652, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (44008879..44029211, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene SREBF pathway regulator in golgi 1 Neighboring gene ring finger protein, transmembrane 2 Neighboring gene uncharacterized LOC102553921 Neighboring gene U6 spliceosomal RNA Neighboring gene F-box and WD repeat domain containing 8 Neighboring gene uncharacterized LOC134481299 Neighboring gene tescalcin

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Signaling by IL-1beta+IFN-gamma and ER stress converge on DP5/Hrk activation: a novel mechanism for pancreatic beta-cell apoptosis. Gurzov EN, et al. Cell Death Differ, 2009 Nov. PMID 19629134
    2. The proapoptotic dp5 gene is a direct target of the MLK-JNK-c-Jun pathway in sympathetic neurons. Towers E, et al. Nucleic Acids Res, 2009 May. PMID 19304750, Free PMC Article
    3. Long Noncoding RNA SOX2-OT Aggravates Doxorubicin-Induced Apoptosis of Cardiomyocyte by Targeting miR-942-5p/DP5. Wang H, et al. Drug Des Devel Ther, 2021. PMID 33603338, Free PMC Article
    4. Glutathione binding to the Bcl-2 homology-3 domain groove: a molecular basis for Bcl-2 antioxidant function at mitochondria. Zimmermann AK, et al. J Biol Chem, 2007 Oct 5. PMID 17690097, Free PMC Article
    5. JNK activation contributes to DP5 induction and apoptosis following traumatic spinal cord injury. Yin KJ, et al. Neurobiol Dis, 2005 Dec. PMID 16005241

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Long Noncoding RNA SOX2-OT Aggravates Doxorubicin-Induced Apoptosis of Cardiomyocyte by Targeting miR-942-5p/DP5.
      Title: Long Noncoding RNA SOX2-OT Aggravates Doxorubicin-Induced Apoptosis of Cardiomyocyte by Targeting miR-942-5p/DP5.
    2. The inactivation of hrk protein protects -cells from IL-1beta+IFN-gamma and chemical Endoplasmic Reticulum stress-mediated cell death.
      Title: Signaling by IL-1beta+IFN-gamma and ER stress converge on DP5/Hrk activation: a novel mechanism for pancreatic beta-cell apoptosis.
    3. identification of a conserved ATF site in the dp5 promoter that binds c-Jun and ATF2, which is critical for dp5 promoter induction after NGF withdrawal.
      Title: The proapoptotic dp5 gene is a direct target of the MLK-JNK-c-Jun pathway in sympathetic neurons.
    4. dp5 is a target gene of c-Jun and plays a critical role in potassium deprivation-induced apoptosis in cerebellar granule neurons.
      Title: dp5/HRK is a c-Jun target gene and required for apoptosis induced by potassium deprivation in cerebellar granule neurons.
    5. Bcl-2 regulates an essential pool of mitochondrial GSH and this regulation may depend upon Bcl-2 directly interacting with GSH via the BH3 groove
      Title: Glutathione binding to the Bcl-2 homology-3 domain groove: a molecular basis for Bcl-2 antioxidant function at mitochondria.
    6. These results suggest that JNK activation contributes to trauma-induced DP5 expression and subsequent apoptosis in SCI.
      Title: JNK activation contributes to DP5 induction and apoptosis following traumatic spinal cord injury.
    7. BH3 peptide has a role in releasing cytochrome c in rat brain mitochondria
      Title: Postnatal brain development and neural cell differentiation modulate mitochondrial Bax and BH3 peptide-induced cytochrome c release.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to potassium ion starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of release of cytochrome c from mitochondria ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    activator of apoptosis harakiri
    Names
    BH3 interacting (with BCL2 family) domain, apoptosis agonist
    BH3 interacting domain 3
    BH3-interacting domain-containing protein 3
    harakiri, BCL2 interacting protein (contains only BH3 domain)
    neuronal death protein DP5

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_057130.5 → NP_476471.1  activator of apoptosis harakiri

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/Swiss-Prot
      P62817
      Related
      ENSRNOP00000106855.1, ENSRNOT00000122802.1
      Conserved Domains (1) summary
      pfam15196
      Location:1 → 92
      Harakiri; Activator of apoptosis harakiri

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      44048402..44070561 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P62817.1 GenPept UniProtKB/Swiss-Prot:P62817

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials