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    Slc17a6 solute carrier family 17 member 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84487, updated on 9-Dec-2024

    Summary

    Official Symbol
    Slc17a6provided by RGD
    Official Full Name
    solute carrier family 17 member 6provided by RGD
    Primary source
    RGD:620531
    See related
    EnsemblRapid:ENSRNOG00000016147 AllianceGenome:RGD:620531
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dnpi; Vglut2
    Summary
    Enables chloride channel activity and secondary active transmembrane transporter activity. Involved in several processes, including hippocampus development; neurotransmitter loading into synaptic vesicle; and sodium-dependent phosphate transport. Located in cytoplasmic vesicle; excitatory synapse; and pericellular basket. Is active in synaptic vesicle membrane. Biomarker of transient cerebral ischemia. Orthologous to human SLC17A6 (solute carrier family 17 member 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 167.2) See more
    Orthologs
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    Genomic context

    See Slc17a6 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (110348447..110388499)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (101212489..101252543)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (106980463..107038717)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene anoctamin 5 Neighboring gene cold shock domain containing E1, pseudogene 1 Neighboring gene uncharacterized LOC134483191 Neighboring gene ribosomal protein L18A, pseudogene 4 Neighboring gene uncharacterized LOC120099815 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables L-glutamate transmembrane transporter activity  
    enables L-glutamate uniporter activity PubMed 
    enables L-glutamate uniporter activity  
    enables L-glutamate uniporter activity  
    enables antiporter activity  
    enables chloride channel activity PubMed 
    enables chloride channel activity  
    enables neurotransmitter transmembrane transporter activity  
    enables phosphate ion uniporter activity  
    enables potassium:proton antiporter activity PubMed 
    enables potassium:proton antiporter activity  
    enables sodium:phosphate symporter activity PubMed 
    enables sodium:phosphate symporter activity  
    enables symporter activity  
    Items 1 - 25 of 28
    Process Evidence Code Pubs
    involved_in L-glutamate import  
    involved_in L-glutamate import  
    involved_in L-glutamate transmembrane transport PubMed 
    involved_in L-glutamate transmembrane transport  
    involved_in L-glutamate transmembrane transport  
    involved_in chloride transmembrane transport  
    involved_in hippocampus development PubMed 
    involved_in hyaloid vascular plexus regression  
    involved_in hyaloid vascular plexus regression  
    involved_in neural retina development PubMed 
    involved_in neurotransmitter loading into synaptic vesicle  
    involved_in neurotransmitter loading into synaptic vesicle PubMed 
    involved_in neurotransmitter loading into synaptic vesicle PubMed 
    involved_in neurotransmitter transport  
    acts_upstream_of_or_within neurotransmitter uptake  
    involved_in phosphate ion homeostasis  
    involved_in phosphate ion homeostasis  
    involved_in phosphate ion homeostasis  
    involved_in phosphate ion transport PubMed 
    involved_in phosphate ion transport  
    involved_in potassium ion transmembrane transport  
    involved_in proton transmembrane transport  
    involved_in regulation of synapse structure or activity  
    involved_in sodium ion transmembrane transport  
    involved_in sodium ion transport  
    involved_in sodium-dependent phosphate transport PubMed 
    involved_in sodium-dependent phosphate transport  
    involved_in synaptic transmission, glutamatergic  
    Items 1 - 25 of 28
    Component Evidence Code Pubs
    part_of chloride channel complex  
    located_in early endosome PubMed 
    is_active_in excitatory synapse  
    located_in excitatory synapse PubMed 
    located_in neuron projection PubMed 
    located_in neuron projection  
    located_in pericellular basket PubMed 
    located_in plasma membrane  
    located_in presynapse  
    located_in synaptic vesicle PubMed 
    located_in synaptic vesicle  
    is_active_in synaptic vesicle membrane  
    is_active_in synaptic vesicle membrane PubMed 
    located_in synaptic vesicle membrane  
    located_in synaptic vesicle membrane  

    General protein information

    Preferred Names
    vesicular glutamate transporter 2
    Names
    differentation-associated Na-dependent inorganic phosphate cotransporter
    differentiation-associated BNPI
    differentiation-associated Na(+)-dependent inorganic phosphate cotransporter
    solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
    solute carrier family 17 (vesicular glutamate transporter), member 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053427.1NP_445879.1  vesicular glutamate transporter 2

      See identical proteins and their annotated locations for NP_445879.1

      Status: PROVISIONAL

      Source sequence(s)
      AF271235
      UniProtKB/Swiss-Prot
      Q9JI12
      UniProtKB/TrEMBL
      A6JBH4, G3V851
      Related
      ENSRNOP00000022383.3, ENSRNOT00000022383.8
      Conserved Domains (2) summary
      cd06174
      Location:75498
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00894
      Location:70511
      2A0114euk; Na(+)-dependent inorganic phosphate cotransporter

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      110348447..110388499
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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