Socs2 suppressor of cytokine signaling 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Socs2provided by RGD
Official Full Name: suppressor of cytokine signaling 2provided by RGD
Primary source: RGD:69273
See related: EnsemblRapid:ENSRNOG00000008965 AllianceGenome:RGD:69273
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cish2; Socs-2
Summary: Predicted to enable phosphorylation-dependent protein binding activity; signaling receptor binding activity; and ubiquitin-like ligase-substrate adaptor activity. Involved in response to peptide hormone. Predicted to be part of Cul5-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in endometrial cancer and ovarian carcinoma. Orthologous to human SOCS2 (suppressor of cytokine signaling 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 354.2), Spleen (RPKM 119.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q13

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (31890564..31932092, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (30006360..30045161, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (36495496..36500878, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

research suggests that overexpressed SOCS2 might exacerbate myocardial ischemia/reperfusion injury in type 2 diabetes mellitus by inhibiting the expression of Insulin-like Growth Factor-1 via the Janus kinase-signal transducer and activator of transcription signaling pathway.
Title: SOCS2 exacerbates myocardial injury induced by ischemia/reperfusion in diabetic mice and H9c2 cells through inhibiting the JAK-STAT-IGF-1 pathway.
SOCS2 is a negative feed back regulator of growth hormone receptor. SOCS2 deletion in mice causes gigantism.
Title: SOCS2 negatively regulates growth hormone action in vitro and in vivo.
SOCS-2 may be involved in glial reactions, and possibly adult hippocampal neurogenesis during ischemic insults.
Title: Enhanced expression of SOCS-2 in the rat hippocampus after transient forebrain ischemia.
insulin can inhibit the mitogenic action of IGF-1 in mesangial cells by regulating STAT5/SOCS2 expression.
Title: Insulin regulates SOCS2 expression and the mitogenic effect of IGF-1 in mesangial cells.
Data show that althhough we observed OVX-related increases in SOCS2 and SOCS3 mRNA, SOCS2 and SOCS3 protein did not differ among groups.
Title: Effect of ovariectomy on cardiac gene expression: inflammation and changes in SOCS gene expression.
SOC-2 induced by GH may play an important role in suppressing collagen accumulation and mesenchymal cell proliferation induced by GH or GH-induced IGF-I
Title: Suppressor of cytokine signaling-2 modulates the fibrogenic actions of GH and IGF-I in intestinal mesenchymal cells.
suppressor of cytokine signaling 2 is a direct signal transducer and activator of transcription 5b target in liver
Title: In vivo transcript profiling and phylogenetic analysis identifies suppressor of cytokine signaling 2 as a direct signal transducer and activator of transcription 5b target in liver.
SOCS-2 displays a relatively higher level of basal expression in the hippocampus than SOCS-1, and a mild, transient downregulation by 24 hr, supporting the hypothesis that seizure-induced gp130 cytokines play a direct neuromodulatory role in the brain.
Title: Differential expression of suppressors of cytokine signaling-1, -2, and -3 in the rat hippocampus after seizure: implications for neuromodulation by gp130 cytokines.
Up-regulation of SOCS2 in neuronal progenitor cells derived from the adult SVZ may regulate erythropoietin enhanced neuronal differentiation.
Title: Erythropoietin up-regulates SOCS2 in neuronal progenitor cells derived from SVZ of adult rat.
SOCS-2 is a growth hormone-inducible, novel inhibitor of intestinal epithelial cell proliferation and intestinal growth.
Title: Suppressor of cytokine signaling-2: a growth hormone-inducible inhibitor of intestinal epithelial cell proliferation.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytokine receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables growth hormone receptor binding	IEA Inferred from Electronic Annotation more info
enables growth hormone receptor binding	ISO Inferred from Sequence Orthology more info
enables insulin-like growth factor receptor binding	IEA Inferred from Electronic Annotation more info
enables insulin-like growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables insulin-like growth factor receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables phosphorylation-dependent protein binding	IEA Inferred from Electronic Annotation more info
enables phosphorylation-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables phosphorylation-dependent protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin-like ligase-substrate adaptor activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-like ligase-substrate adaptor activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-like ligase-substrate adaptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cell surface receptor signaling pathway via JAK-STAT	IEA Inferred from Electronic Annotation more info
acts_upstream_of cell surface receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hormone stimulus	ISO Inferred from Sequence Orthology more info
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in growth hormone receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in growth hormone receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in lactation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lactation	ISO Inferred from Sequence Orthology more info
involved_in mammary gland alveolus development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mammary gland alveolus development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of growth hormone receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of growth hormone receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of growth hormone receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of multicellular organism growth	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of multicellular organism growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of receptor signaling pathway via JAK-STAT	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of multicellular organism growth	ISO Inferred from Sequence Orthology more info
involved_in response to estradiol	IEA Inferred from Electronic Annotation more info
involved_in response to estradiol	ISO Inferred from Sequence Orthology more info
involved_in response to peptide hormone	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
part_of Cul5-RING ubiquitin ligase complex	IEA Inferred from Electronic Annotation more info
part_of Cul5-RING ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of Cul5-RING ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: suppressor of cytokine signaling 2

Names: cytokine inducible SH2-containing protein 2; cytokine-inducible SH2 protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_058208.2 → NP_478115.1 suppressor of cytokine signaling 2

See identical proteins and their annotated locations for NP_478115.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

O88582

UniProtKB/TrEMBL

A6IG31, A6IG33

Conserved Domains (2) summary

cd10383
Location:40 → 142

SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins

cl02533
Location:158 → 198

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

31890564..31932092 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039079991.2 → XP_038935919.1 suppressor of cytokine signaling 2 isoform X1

UniProtKB/TrEMBL

A6IG31

Conserved Domains (2) summary

cd10383
Location:40 → 142

SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins

cl02533
Location:158 → 197

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
XM_039079992.2 → XP_038935920.1 suppressor of cytokine signaling 2 isoform X1

UniProtKB/TrEMBL

A6IG31

Related

ENSRNOP00000089730.2, ENSRNOT00000103867.2

Conserved Domains (2) summary

cd10383
Location:40 → 142

SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins

cl02533
Location:158 → 197

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
XM_039079993.2 → XP_038935921.1 suppressor of cytokine signaling 2 isoform X3

UniProtKB/TrEMBL

A0A8I6AD64, A6IG31

Related

ENSRNOP00000100589.1, ENSRNOT00000167189.1

Conserved Domains (2) summary

cd10383
Location:40 → 142

SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins

cl02533
Location:158 → 197

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
XM_017595137.3 → XP_017450626.1 suppressor of cytokine signaling 2 isoform X2

UniProtKB/Swiss-Prot

O88582

UniProtKB/TrEMBL

A6IG31, A6IG33

Conserved Domains (2) summary

cd10383
Location:40 → 142

SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins

cl02533
Location:158 → 198

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
XM_063264346.1 → XP_063120416.1 suppressor of cytokine signaling 2 isoform X2

UniProtKB/Swiss-Prot

O88582

UniProtKB/TrEMBL

A6IG31, A6IG33
XM_063264345.1 → XP_063120415.1 suppressor of cytokine signaling 2 isoform X2

UniProtKB/Swiss-Prot

O88582

UniProtKB/TrEMBL

A6IG31, A6IG33
XM_063264347.1 → XP_063120417.1 suppressor of cytokine signaling 2 isoform X4