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    Tsen34 tRNA splicing endonuclease subunit 34 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 292534, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tsen34provided by RGD
    Official Full Name
    tRNA splicing endonuclease subunit 34provided by RGD
    Primary source
    RGD:1359564
    See related
    EnsemblRapid:ENSRNOG00000059572 AllianceGenome:RGD:1359564
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    LENG5; SEN34; Tsen34l1
    Summary
    Predicted to enable tRNA-intron endonuclease activity. Predicted to be involved in tRNA-type intron splice site recognition and cleavage. Predicted to be located in nucleoplasm. Predicted to be part of tRNA-intron endonuclease complex. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 2C. Orthologous to human TSEN34 (tRNA splicing endonuclease subunit 34). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 183.6), Kidney (RPKM 182.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tsen34 in Genome Data Viewer
    Location:
    1q12
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (74432687..74440553, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (65517324..65525194, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (64023924..64031756, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene leukocyte immunoglobulin like receptor B1 Neighboring gene paired Ig-like receptor B Neighboring gene ribosomal protein S9 Neighboring gene membrane bound O-acyltransferase domain containing 7 Neighboring gene transmembrane channel-like 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Handling tRNA introns, archaeal way and eukaryotic way. Yoshihisa T. Front Genet, 2014. PMID 25071838, Free PMC Article
    2. Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation. Paushkin SV, et al. Cell, 2004 Apr 30. PMID 15109492
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94712

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA-intron endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA-type intron splice site recognition and cleavage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of tRNA-intron endonuclease complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tRNA-splicing endonuclease subunit Sen34
    Names
    TSEN34 tRNA splicing endonuclease subunit
    leukocyte receptor cluster (LRC) member 5
    tRNA splicing endonuclease 34 homolog
    tRNA splicing endonuclease subunit 34-like 1
    tRNA-splicing endonuclease subunit Sen34-like
    NP_001006969.1
    NP_001406968.1
    XP_006228137.1
    XP_008757061.1
    XP_017444128.1
    XP_038959609.1
    XP_038959611.1
    XP_063139005.1
    XP_063139006.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001006968.2 → NP_001006969.1  tRNA-splicing endonuclease subunit Sen34

      See identical proteins and their annotated locations for NP_001006969.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A0G2K071, F1LSA6, Q5XIB7
      Conserved Domains (1) summary
      cd22363
      Location:220 → 308
      tRNA-intron_lyase_C; catalytic C-terminal domain of the tRNA-intron lyase

    2. NM_001313942.1 → NP_001300871.1  tRNA-splicing endonuclease subunit Sen34

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A0G2K071, F1LSA6, Q5XIB7

    3. NM_001420039.1 → NP_001406968.1  tRNA-splicing endonuclease subunit Sen34

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A0G2K071, F1LSA6, Q5XIB7
      Related
      ENSRNOP00000071330.1, ENSRNOT00000084846.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      74432687..74440553 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039103683.2 → XP_038959611.1  tRNA-splicing endonuclease subunit Sen34 isoform X1

      Conserved Domains (1) summary
      cd22363
      Location:220 → 308
      tRNA-intron_lyase_C; catalytic C-terminal domain of the tRNA-intron lyase

    2. XM_063282935.1 → XP_063139005.1  tRNA-splicing endonuclease subunit Sen34 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K071, F1LSA6, Q5XIB7

    3. XM_017588639.3 → XP_017444128.1  tRNA-splicing endonuclease subunit Sen34 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K071, F1LSA6, Q5XIB7
      Conserved Domains (1) summary
      cd22363
      Location:220 → 308
      tRNA-intron_lyase_C; catalytic C-terminal domain of the tRNA-intron lyase

    4. XM_006228075.5 → XP_006228137.1  tRNA-splicing endonuclease subunit Sen34 isoform X1

      See identical proteins and their annotated locations for XP_006228137.1

      UniProtKB/TrEMBL
      A0A0G2K071, F1LSA6, Q5XIB7
      Conserved Domains (1) summary
      cd22363
      Location:220 → 308
      tRNA-intron_lyase_C; catalytic C-terminal domain of the tRNA-intron lyase

    5. XM_039103681.2 → XP_038959609.1  tRNA-splicing endonuclease subunit Sen34 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K071, F1LSA6, Q5XIB7
      Conserved Domains (1) summary
      cd22363
      Location:220 → 308
      tRNA-intron_lyase_C; catalytic C-terminal domain of the tRNA-intron lyase

    6. XM_063282936.1 → XP_063139006.1  tRNA-splicing endonuclease subunit Sen34 isoform X2

    7. XM_008758839.4 → XP_008757061.1  tRNA-splicing endonuclease subunit Sen34 isoform X2

      See identical proteins and their annotated locations for XP_008757061.1

      Conserved Domains (2) summary
      pfam01974
      Location:219 → 250
      tRNA_int_endo; tRNA intron endonuclease, catalytic C-terminal domain
      pfam03985
      Location:102 → 168
      Paf1; Paf1
    Nucleotide Protein Strain
    Heading Accession and Version

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