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    C12h12orf43 similar to human chromosome 12 open reading frame 43 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288704, updated on 9-Dec-2024

    Summary

    Official Symbol
    C12h12orf43provided by RGD
    Official Full Name
    similar to human chromosome 12 open reading frame 43provided by RGD
    Primary source
    RGD:1311899
    See related
    EnsemblRapid:ENSRNOG00000001185 AllianceGenome:RGD:1311899
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Custos; C12orf43l; RGD1311899
    Summary
    Predicted to be involved in Spemann organizer formation and negative regulation of Wnt signaling pathway. Predicted to be located in nuclear envelope. Orthologous to human C12orf43 (chromosome 12 open reading frame 43). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 480.7), Kidney (RPKM 324.4) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See C12h12orf43 in Genome Data Viewer
    Location:
    12q16
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (47332740..47338461, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (41672089..41677722, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (47433355..47438960, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene acyl-CoA dehydrogenase short chain Neighboring gene signal peptide peptidase like 3 Neighboring gene HNF1 homeobox A Neighboring gene uncharacterized LOC134481304 Neighboring gene 2'-5'-oligoadenylate synthetase-like Neighboring gene uncharacterized LOC120096007 Neighboring gene 2'-5' oligoadenylate synthetase-like 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Clone Names

    • MGC105760

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in Spemann organizer formation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    protein CUSTOS
    Names
    chromosome 12 open reading frame 43 like
    uncharacterized protein C12orf43 homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009630.2NP_001009630.1  protein CUSTOS

      See identical proteins and their annotated locations for NP_001009630.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/Swiss-Prot
      Q5I034
      UniProtKB/TrEMBL
      A0A8I6B0G7, A6J1X6
      Related
      ENSRNOP00000094392.1, ENSRNOT00000115017.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      47332740..47338461 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006249433.4XP_006249495.1  protein CUSTOS isoform X1

      UniProtKB/TrEMBL
      A0A8I6AWB0, A6J1X5
      Related
      ENSRNOP00000092927.1, ENSRNOT00000099006.2
    2. XM_063271214.1XP_063127284.1  protein CUSTOS isoform X3

    3. XM_039089267.2XP_038945195.1  protein CUSTOS isoform X2