Lrrc8d leucine rich repeat containing 8 VRAC subunit D [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lrrc8dprovided by RGD
Official Full Name: leucine rich repeat containing 8 VRAC subunit Dprovided by RGD
Primary source: RGD:1309601
See related: EnsemblRapid:ENSRNOG00000002121 AllianceGenome:RGD:1309601
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Lrrc5
Summary: Contributes to volume-sensitive anion channel activity. Involved in aspartate transmembrane transport; cellular response to osmotic stress; and taurine transmembrane transport. Part of monoatomic ion channel complex. Orthologous to human LRRC8D (leucine rich repeat containing 8 VRAC subunit D). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 255.5), Adrenal (RPKM 129.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14p22

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (4335114..4411549, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (4029971..4134922, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (5085606..5194808, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables volume-sensitive anion channel activity	IEA Inferred from Electronic Annotation more info
contributes_to volume-sensitive anion channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
contributes_to volume-sensitive anion channel activity	ISO Inferred from Sequence Orthology more info
enables volume-sensitive anion channel activity	ISO Inferred from Sequence Orthology more info
contributes_to volume-sensitive anion channel activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in aspartate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in aspartate transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in aspartate transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in aspartate transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in aspartate transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to osmotic stress	IEA Inferred from Electronic Annotation more info
involved_in cellular response to osmotic stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to osmotic stress	ISO Inferred from Sequence Orthology more info
involved_in cellular response to osmotic stress	ISS Inferred from Sequence or Structural Similarity more info
NOT involved_in cyclic-GMP-AMP transmembrane import across plasma membrane	ISO Inferred from Sequence Orthology more info
NOT involved_in cyclic-GMP-AMP transmembrane import across plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular glucose homeostasis	IEA Inferred from Electronic Annotation more info
involved_in intracellular glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular glucose homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic anion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic anion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic anion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in monoatomic anion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein hexamerization	IEA Inferred from Electronic Annotation more info
involved_in protein hexamerization	ISO Inferred from Sequence Orthology more info
involved_in protein hexamerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in taurine transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in taurine transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in taurine transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in taurine transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of monoatomic ion channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of monoatomic ion channel complex	IEA Inferred from Electronic Annotation more info
part_of monoatomic ion channel complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of monoatomic ion channel complex	ISO Inferred from Sequence Orthology more info
part_of monoatomic ion channel complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: volume-regulated anion channel subunit LRRC8D

Names: leucine rich repeat containing 8 family, member D; leucine rich repeat containing 8D; leucine-rich repeat-containing 5; leucine-rich repeat-containing protein 5; leucine-rich repeat-containing protein 8D

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008338.1 → NP_001008339.2 volume-regulated anion channel subunit LRRC8D

Status: VALIDATED

Source sequence(s)

BC085783

UniProtKB/TrEMBL

A0A0H2UHA3

Conserved Domains (5) summary

cd00116
Location:557 → 834

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00031
Location:517 → 538

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:639 → 661

LRR_RI; leucine-rich repeat [structural motif]

pfam12534
Location:3 → 386

Pannexin_like; Pannexin-like TM region of LRRC8

pfam13855
Location:638 → 697

LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

4335114..4411549 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039091810.2 → XP_038947738.1 volume-regulated anion channel subunit LRRC8D isoform X1

UniProtKB/Swiss-Prot

Q5U308

UniProtKB/TrEMBL

A6K5Q0

Related

ENSRNOP00000091428.1, ENSRNOT00000105738.2

Conserved Domains (5) summary

COG4886
Location:596 → 825

LRR; Leucine-rich repeat (LRR) protein [Transcription]

sd00031
Location:515 → 536

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:637 → 659

LRR_RI; leucine-rich repeat [structural motif]

pfam12534
Location:1 → 384

Pannexin_like; Pannexin-like TM region of LRRC8

NF033190
Location:456 → 702

inl_like_NEAT_1; NEAT domain-containing leucine-rich repeat protein