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    Ifgga2l1 interferon-gamma-inducible GTPase 2 like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307414, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ifgga2l1provided by RGD
    Official Full Name
    interferon-gamma-inducible GTPase 2 like 1provided by RGD
    Primary source
    RGD:1359421
    See related
    EnsemblRapid:ENSRNOG00000019542 AllianceGenome:RGD:1359421
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ifgga3; Ifgga2l
    Summary
    Predicted to enable GTPase activity. Predicted to be involved in autophagosome assembly; cellular response to interferon-beta; and innate immune response. Predicted to be active in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 371.6), Thymus (RPKM 288.8) and 8 other tissues See more
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    Genomic context

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    See Ifgga2l1 in Genome Data Viewer
    Location:
    18q12.1
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (56031907..56040627)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (53761118..53770183)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (55576239..55584959)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene large ribosomal subunit protein eL13-like Neighboring gene similar to interferon-inducible GTPase Neighboring gene interferon-inducible GTPase 1-like Neighboring gene interferon-gamma-inducible GTPase 2 like, pseudogene 2 Neighboring gene interferon-gamma-inducible GTPase 4 like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC108823

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to interferon-beta IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    interferon-gamma-inducible GTPase 2 like 1
    Names
    Interferon-inducible GTPase 1
    interferon-gamma-inducible GTPase Ifgga3 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012353.1 → NP_001012353.1  interferon-gamma-inducible GTPase 2 like 1

      See identical proteins and their annotated locations for NP_001012353.1

      Status: PROVISIONAL

      Source sequence(s)
      BC089836
      UniProtKB/TrEMBL
      F7F0H6, Q5FVQ6
      Related
      ENSRNOP00000082693.1, ENSRNOT00000117683.2
      Conserved Domains (3) summary
      cd04104
      Location:68 → 264
      p47_IIGP_like; p47 GTPase family includes IGTP, TGTP/Mg21, IRG-47, GTPI, LRG-47, and IIGP1
      pfam05049
      Location:34 → 408
      IIGP; Interferon-inducible GTPase (IIGP)
      cl21455
      Location:20 → 90
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      56031907..56040627
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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