Obi1 ORC ubiquitin ligase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Obi1provided by RGD
Official Full Name: ORC ubiquitin ligase 1provided by RGD
Primary source: RGD:1564706
See related: EnsemblRapid:ENSRNOG00000009690 AllianceGenome:RGD:1564706
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Rnf219; RGD1564706
Summary: Predicted to enable chromatin binding activity and ubiquitin-protein transferase activity. Predicted to be involved in protein autoubiquitination; protein monoubiquitination; and regulation of DNA replication. Predicted to act upstream of or within positive regulation of mRNA splicing, via spliceosome. Predicted to be located in chromatin. Orthologous to human OBI1 (ORC ubiquitin ligase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 72.7), Spleen (RPKM 64.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15q22

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (87684022..87723342, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (81269413..81308734, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (88632089..88670325, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within positive regulation of mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in protein autoubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein monoubiquitination	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA replication	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in chromatin	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ORC ubiquitin ligase 1

Names: ring finger protein 219

NP_001101859.1

EC 2.3.2.27

XP_038949465.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108389.1 → NP_001101859.1 ORC ubiquitin ligase 1

See identical proteins and their annotated locations for NP_001101859.1

Status: PROVISIONAL

Source sequence(s)

CH473951

UniProtKB/TrEMBL

A0A8I6A402, A6HUB2, D3ZAB6

Related

ENSRNOP00000012880.5, ENSRNOT00000012881.8

Conserved Domains (3) summary

COG5432
Location:18 → 97

RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

TIGR02168
Location:90 → 253

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd16562
Location:15 → 56

RING-HC_RNF219; RING finger, HC subclass, found in RING finger protein 219 (RNF219) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

87684022..87723342 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039093537.2 → XP_038949465.1 ORC ubiquitin ligase 1 isoform X1

UniProtKB/TrEMBL

A0A8I6A402

Conserved Domains (1) summary

TIGR02168
Location:13 → 176

SMC_prok_B; chromosome segregation protein SMC, common bacterial type