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    Septin6 septin 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 691335, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Septin6provided by RGD
    Official Full Name
    septin 6provided by RGD
    Primary source
    RGD:1585082
    See related
    EnsemblRapid:ENSRNOG00000043182 AllianceGenome:RGD:1585082
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Sept6
    Summary
    Predicted to enable GTPase activity and molecular adaptor activity. Predicted to be involved in cilium assembly; cytoskeleton-dependent cytokinesis; and protein localization. Predicted to be located in several cellular components, including cleavage furrow; septin collar; and sperm annulus. Predicted to be part of septin complex. Predicted to be active in cell division site; cytoskeleton; and presynapse. Orthologous to human SEPTIN6 (septin 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 241.9), Spleen (RPKM 119.5) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Septin6 in Genome Data Viewer
    Location:
    Xq34
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (121018951..121157677, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (116153255..116230334, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (123524954..123601214, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2A Neighboring gene NFKB repressing factor Neighboring gene sosondowah ankyrin repeat domain family member D Neighboring gene small nucleolar RNA SNORA69 Neighboring gene ribosomal protein L39

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Septin 6 regulates the cytoarchitecture of neurons through localization at dendritic branch points and bases of protrusions. Cho SJ, et al. Mol Cells, 2011 Jul. PMID 21544625, Free PMC Article
    2. Effect of SEPT6 on the biological behavior of hepatic stellate cells and liver fibrosis in rats and its mechanism. Fan Y, et al. Lab Invest, 2019 Jan. PMID 30315255
    3. The septin cytoskeleton facilitates membrane retraction during motility and blebbing. Gilden JK, et al. J Cell Biol, 2012 Jan 9. PMID 22232702, Free PMC Article
    4. SEPT12 orchestrates the formation of mammalian sperm annulus by organizing core octameric complexes with other SEPT proteins. Kuo YC, et al. J Cell Sci, 2015 Mar 1. PMID 25588830
    5. Differential localization of septins in the mouse brain. Kinoshita A, et al. J Comp Neurol, 2000 Dec 11. PMID 11064363

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. regulates various biological behaviors in hepatic stellate cells through TGF-beta1/Smad, mitogen-activated protein kinases and phosphatidylinositol-3-kinase/protein kinase B signaling pathways, thus promoting liver fibrosis
      Title: Effect of SEPT6 on the biological behavior of hepatic stellate cells and liver fibrosis in rats and its mechanism.
    2. Septin 6 regulates the cytoarchitecture of neurons through localization at dendritic branch points and bases of protrusions.
      Title: Septin 6 regulates the cytoarchitecture of neurons through localization at dendritic branch points and bases of protrusions.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC189443

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoskeleton-dependent cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in axon terminus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cell division site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cleavage furrow ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in presynapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in septin collar ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of septin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of septin complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in septin ring IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in septin ring ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm annulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    septin-6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001173429.1 → NP_001166900.1  septin-6

      See identical proteins and their annotated locations for NP_001166900.1

      Status: PROVISIONAL

      Source sequence(s)
      BC169051
      UniProtKB/TrEMBL
      A0A0U1RRN9, A0A9K3Y7T9, B5DFG5, F1LRN3
      Related
      ENSRNOP00000061494.2, ENSRNOT00000067942.5
      Conserved Domains (2) summary
      cd01850
      Location:39 → 307
      CDC_Septin; CDC/Septin GTPase family
      COG5019
      Location:21 → 373
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      121018951..121157677 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063280318.1 → XP_063136388.1  septin-6 isoform X7

      UniProtKB/TrEMBL
      A0A0U1RRN9, A0A0U1RRT8, A6JMG9
      Related
      ENSRNOP00000075809.2, ENSRNOT00000092546.3

    2. XM_017602159.3 → XP_017457648.1  septin-6 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZSZ7

    3. XM_063280315.1 → XP_063136385.1  septin-6 isoform X5

      UniProtKB/TrEMBL
      A0A0U1RRN9, A0A8I6AA08, A6JMH0

    4. XM_063280316.1 → XP_063136386.1  septin-6 isoform X5

      UniProtKB/TrEMBL
      A0A0U1RRN9, A0A8I6AA08, A6JMH0

    5. XM_006257463.5 → XP_006257525.1  septin-6 isoform X5

      See identical proteins and their annotated locations for XP_006257525.1

      UniProtKB/TrEMBL
      A0A0U1RRN9, A0A8I6AA08, A6JMH0
      Related
      ENSRNOP00000088464.2, ENSRNOT00000109309.2
      Conserved Domains (2) summary
      cd01850
      Location:39 → 307
      CDC_Septin; CDC/Septin GTPase family
      COG5019
      Location:21 → 373
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

    6. XM_063280319.1 → XP_063136389.1  septin-6 isoform X8

      UniProtKB/TrEMBL
      A0A0U1RRN9, A0A9K3Y7T9, B5DFG5, F1LRN3

    7. XM_017602157.3 → XP_017457646.1  septin-6 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZSZ7

    8. XM_017602161.3 → XP_017457650.1  septin-6 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZSZ7

    9. XM_063280320.1 → XP_063136390.1  septin-6 isoform X9

      UniProtKB/TrEMBL
      A0A8I5ZSZ7

    10. XM_063280317.1 → XP_063136387.1  septin-6 isoform X6

      UniProtKB/TrEMBL
      A0A0U1RRN9
      Related
      ENSRNOP00000075833.2, ENSRNOT00000092670.3

    11. XM_017602158.3 → XP_017457647.1  septin-6 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZSZ7
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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