Ldlrad4 low density lipoprotein receptor class A domain containing 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ldlrad4provided by RGD
Official Full Name: low density lipoprotein receptor class A domain containing 4provided by RGD
Primary source: RGD:1587105
See related: EnsemblRapid:ENSRNOG00000016879 AllianceGenome:RGD:1587105
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable R-SMAD binding activity. Predicted to be involved in negative regulation of cell migration; negative regulation of epithelial to mesenchymal transition; and negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in Golgi membrane and early endosome membrane. Orthologous to human LDLRAD4 (low density lipoprotein receptor class A domain containing 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 56.2), Kidney (RPKM 51.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 18q12.1

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (63789089..64118166)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (61519253..61848403)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (63717423..64045224)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH128670 (e-PCR)
- UniSTS:211978

BF386607 (e-PCR)
- UniSTS:243795

BF399308 (e-PCR)
- UniSTS:247638

D18Mit16 (e-PCR), detects polymorphism
- UniSTS:240580

RH138542 (e-PCR)
- UniSTS:220629

RH131736 (e-PCR)
- UniSTS:215019

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables R-SMAD binding	IBA Inferred from Biological aspect of Ancestor more info
enables R-SMAD binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in early endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome membrane	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: low-density lipoprotein receptor class A domain-containing protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001271365.1 → NP_001258294.1 low-density lipoprotein receptor class A domain-containing protein 4

See identical proteins and their annotated locations for NP_001258294.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000018

UniProtKB/TrEMBL

A0A8I5ZUC8, A6IXW6

Conserved Domains (1) summary

cd00112
Location:16 → 47

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086036.1 Reference GRCr8

Range

63789089..64118166

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039097102.2 → XP_038953030.1 low-density lipoprotein receptor class A domain-containing protein 4 isoform X1

UniProtKB/TrEMBL

A0A8I5ZUC8, A6IXW6

Conserved Domains (1) summary

cd00112
Location:16 → 47

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
XM_039097106.2 → XP_038953034.1 low-density lipoprotein receptor class A domain-containing protein 4 isoform X1

UniProtKB/TrEMBL

A0A8I5ZUC8, A6IXW6

Conserved Domains (1) summary

cd00112
Location:16 → 47

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
XM_039097104.2 → XP_038953032.1 low-density lipoprotein receptor class A domain-containing protein 4 isoform X1

UniProtKB/TrEMBL

A0A8I5ZUC8, A6IXW6

Conserved Domains (1) summary

cd00112
Location:16 → 47

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
XM_039097100.2 → XP_038953028.1 low-density lipoprotein receptor class A domain-containing protein 4 isoform X1

UniProtKB/TrEMBL

A0A8I5ZUC8, A6IXW6

Related

ENSRNOP00000082880.1, ENSRNOT00000113866.2

Conserved Domains (1) summary

cd00112
Location:16 → 47

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
XM_063277574.1 → XP_063133644.1 low-density lipoprotein receptor class A domain-containing protein 4 isoform X4
XM_039097109.2 → XP_038953037.1 low-density lipoprotein receptor class A domain-containing protein 4 isoform X1

UniProtKB/TrEMBL

A0A8I5ZUC8, A6IXW6

Conserved Domains (1) summary

cd00112
Location:16 → 47

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
XM_063277575.1 → XP_063133645.1 low-density lipoprotein receptor class A domain-containing protein 4 isoform X4
XM_039097101.2 → XP_038953029.1 low-density lipoprotein receptor class A domain-containing protein 4 isoform X1

UniProtKB/TrEMBL

A0A8I5ZUC8, A6IXW6

Conserved Domains (1) summary

cd00112
Location:16 → 47

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
XM_063277573.1 → XP_063133643.1 low-density lipoprotein receptor class A domain-containing protein 4 isoform X1

UniProtKB/TrEMBL

A0A8I5ZUC8, A6IXW6
XM_039097105.2 → XP_038953033.1 low-density lipoprotein receptor class A domain-containing protein 4 isoform X1

UniProtKB/TrEMBL

A0A8I5ZUC8, A6IXW6

Conserved Domains (1) summary

cd00112
Location:16 → 47

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
XM_039097103.2 → XP_038953031.1 low-density lipoprotein receptor class A domain-containing protein 4 isoform X1

UniProtKB/TrEMBL

A0A8I5ZUC8, A6IXW6

Conserved Domains (1) summary

cd00112
Location:16 → 47

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
XM_039097098.2 → XP_038953026.1 low-density lipoprotein receptor class A domain-containing protein 4 isoform X1

UniProtKB/TrEMBL

A0A8I5ZUC8, A6IXW6

Conserved Domains (1) summary

cd00112
Location:16 → 47

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
XM_039097112.2 → XP_038953040.1 low-density lipoprotein receptor class A domain-containing protein 4 isoform X2

Conserved Domains (1) summary

cd00112
Location:16 → 47

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
XM_039097107.2 → XP_038953035.1 low-density lipoprotein receptor class A domain-containing protein 4 isoform X1

UniProtKB/TrEMBL

A0A8I5ZUC8, A6IXW6

Conserved Domains (1) summary

cd00112
Location:16 → 47

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
XM_039097111.2 → XP_038953039.1 low-density lipoprotein receptor class A domain-containing protein 4 isoform X1

UniProtKB/TrEMBL

A0A8I5ZUC8, A6IXW6

Conserved Domains (1) summary

cd00112
Location:16 → 47

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
XM_039097110.2 → XP_038953038.1 low-density lipoprotein receptor class A domain-containing protein 4 isoform X1

UniProtKB/TrEMBL

A0A8I5ZUC8, A6IXW6

Conserved Domains (1) summary

cd00112
Location:16 → 47

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
XM_039097108.2 → XP_038953036.1 low-density lipoprotein receptor class A domain-containing protein 4 isoform X1

UniProtKB/TrEMBL

A0A8I5ZUC8, A6IXW6

Conserved Domains (1) summary

cd00112
Location:16 → 47

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
XM_039097117.2 → XP_038953045.1 low-density lipoprotein receptor class A domain-containing protein 4 isoform X6

UniProtKB/TrEMBL

A6IXW9
XM_039097116.2 → XP_038953044.1 low-density lipoprotein receptor class A domain-containing protein 4 isoform X5
XM_039097113.2 → XP_038953041.1 low-density lipoprotein receptor class A domain-containing protein 4 isoform X3

UniProtKB/TrEMBL

A0A0G2K955, A6IXW8, F1LZA8
XM_063277576.1 → XP_063133646.1 low-density lipoprotein receptor class A domain-containing protein 4 isoform X7