Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kcnj5provided by RGD
Official Full Name: potassium inwardly-rectifying channel, subfamily J, member 5provided by RGD
Primary source: RGD:61971
See related: EnsemblRapid:ENSRNOG00000033796 AllianceGenome:RGD:61971
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable inward rectifier potassium channel activity and voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization. Predicted to be involved in cardiac conduction; potassium ion import across plasma membrane; and regulation of monoatomic ion transmembrane transport. Located in T-tubule and external side of plasma membrane. Human ortholog(s) of this gene implicated in atrial fibrillation; long QT syndrome 13; and primary hyperaldosteronism. Orthologous to human KCNJ5 (potassium inwardly rectifying channel subfamily J member 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 183.1), Lung (RPKM 29.3) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q21

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (38981598..39011197, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (30724923..30753083, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (33435493..33463410, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Blocking IK,ACh-c by tertiapin significantly decreased DFT, which correlated with a significant increase in wavelength during reentry. Genetic knockdown experiments with Kcnj5-specific shRNA to modulate IK,ACh-c, yielded similar results
Title: Constitutively Active Acetylcholine-Dependent Potassium Current Increases Atrial Defibrillation Threshold by Favoring Post-Shock Re-Initiation.
The KCNJ5 gene and Kir3.4 protein were measured, and acetylcholine-sensitive potassium channel currents were recorded by patch-clamp.
Title: Effect of small interference RNA on the acetylcholine-sensitive potassium channel in H9c2 cells.
localized in intercalated discs in rat ventricle, whereas it was expressed in intercalated discs and outer sarcolemmas in rat atrium
Title: G-protein-coupled inward rectifier potassium current contributes to ventricular repolarization.
the GIRK4 channel protein plays a role in regulating membrane excitability in chemically defined neurons of the arcuate nucleus that control body weight
Title: G-protein-gated inwardly rectifying K+ channel 4 (GIRK4) immunoreactivity in chemically defined neurons of the hypothalamic arcuate nucleus that control body weight.
Estradiol regulates dopamine-activataed GIRK channel activity in pituitary lactotrophs, regulating prolactin release during the estrous cycle.
Title: Estrogen regulation of the dopamine-activated GIRK channel in pituitary lactotrophs: implications for regulation of prolactin release during the estrous cycle.
All these findings suggest a new role for the K(ATP) channel as a molecular sensor of atrophy.
Title: The KATP channel is a molecular sensor of atrophy in skeletal muscle.
hydrogen sulfide-induced increase in I(K,ATP) on both atrial and ventricular myocytes was concentration dependent
Title: Hydrogen sulfide opens the KATP channel on rat atrial and ventricular myocytes.
Galpha(q) interacted with N termini of Kir3.1, Kir3.2, and Kir3.4. However, Galpha(q) did not interact with the C terminus of any Kir3
Title: Interaction of Galphaq and Kir3, G protein-coupled inwardly rectifying potassium channels.
The point mutation L337R in the GIRK4 C terminus decreased the association between the N and C termini.
Title: Mutation of critical GIRK subunit residues disrupts N- and C-termini association and channel function.

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General gene information

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Markers

AW530580 (e-PCR)
- UniSTS:244540

Kcnj5 (e-PCR), detects polymorphism
- UniSTS:498312

RH133266 (e-PCR)
- UniSTS:216549

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G-protein activated inward rectifier potassium channel activity	IEA Inferred from Electronic Annotation more info
enables G-protein activated inward rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info
enables inward rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to inward rectifier potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables inward rectifier potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to inward rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info
enables inward rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info
enables voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization	IEA Inferred from Electronic Annotation more info
enables voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in membrane repolarization during atrial cardiac muscle cell action potential	IEA Inferred from Electronic Annotation more info
involved_in membrane repolarization during atrial cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info
involved_in potassium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in potassium ion import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transmembrane transport	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of heart rate by cardiac conduction	IEA Inferred from Electronic Annotation more info
involved_in regulation of heart rate by cardiac conduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of monoatomic ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of I(KACh) inward rectifier potassium channel complex	ISO Inferred from Sequence Orthology more info
located_in T-tubule	IDA Inferred from Direct Assay more info	PubMed
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	IEA Inferred from Electronic Annotation more info
part_of voltage-gated potassium channel complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: G protein-activated inward rectifier potassium channel 4

Names: CIR; GIRK-4; GIRK4; KATP-1; cardiac inward rectifier; heart KATP channel; inward rectifier K(+) channel Kir3.4; potassium channel, inwardly rectifying subfamily J member 5; potassium voltage-gated channel subfamily J member 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017297.2 → NP_058993.1 G protein-activated inward rectifier potassium channel 4

See identical proteins and their annotated locations for NP_058993.1

Status: PROVISIONAL

Source sequence(s)

BC087022

UniProtKB/Swiss-Prot

P48548

Related

ENSRNOP00000048134.5, ENSRNOT00000041038.7

Conserved Domains (2) summary

pfam01007
Location:54 → 193

IRK; Inward rectifier potassium channel

pfam17655
Location:200 → 371

IRK_C; Inward rectifier potassium channel C-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

38981598..39011197 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039080975.2 → XP_038936903.1 G protein-activated inward rectifier potassium channel 4 isoform X2

UniProtKB/TrEMBL

A0A8I6G4T8

Related

ENSRNOP00000079101.1, ENSRNOT00000110676.2

Conserved Domains (2) summary

pfam01007
Location:73 → 212

IRK; Inward rectifier potassium channel

pfam17655
Location:219 → 390

IRK_C; Inward rectifier potassium channel C-terminal domain
XM_039080976.2 → XP_038936904.1 G protein-activated inward rectifier potassium channel 4 isoform X3

UniProtKB/Swiss-Prot

P48548

Conserved Domains (2) summary

pfam01007
Location:54 → 193

IRK; Inward rectifier potassium channel

pfam17655
Location:200 → 371

IRK_C; Inward rectifier potassium channel C-terminal domain
XM_039080977.2 → XP_038936905.1 G protein-activated inward rectifier potassium channel 4 isoform X3

UniProtKB/Swiss-Prot

P48548

Conserved Domains (2) summary

pfam01007
Location:54 → 193

IRK; Inward rectifier potassium channel

pfam17655
Location:200 → 371

IRK_C; Inward rectifier potassium channel C-terminal domain
XM_063265036.1 → XP_063121106.1 G protein-activated inward rectifier potassium channel 4 isoform X3

UniProtKB/Swiss-Prot

P48548
XM_063265035.1 → XP_063121105.1 G protein-activated inward rectifier potassium channel 4 isoform X1

Related

ENSRNOP00000099016.1, ENSRNOT00000159264.1