Spink1l serine peptidase inhibitor, Kazal type 1-like [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Spink1lprovided by RGD
Full Name: serine peptidase inhibitor, Kazal type 1-likeprovided by RGD
Primary source: RGD:708468
See related: EnsemblRapid:ENSRNOG00000090734 AllianceGenome:RGD:708468
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Psti; Spink1; Spink3; PSTI-56
Summary: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of peptidase activity. Predicted to be located in extracellular region. Human ortholog(s) of this gene implicated in pancreatitis. Orthologous to human SPINK1 (serine peptidase inhibitor Kazal type 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 3142.2), Liver (RPKM 2195.2) and 1 other tissue See more
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Genomic context

Location:: 18q11

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (36077512..36086696, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (35826607..35835791, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (38177441..38185812, complement)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

that expression of the pancreatic secretory trypsin inhibitor II gene declines drastically during aging, which might result in a lack of protection from prematurely activated trypsin-like proteases
Title: Decreased expression of the pancreatic secretory trypsin inhibitor II gene during aging of the rat liver.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: serine protease inhibitor Kazal-type 1-like

Names: PSTI-II; calcium transport inhibitor; caltrin; pancreatic secretory trypsin inhibitor II; pancreatic secretory trypsin inhibitor type II (PSTI-II); pancreatic secretory trypsin inhibitor-56; serine peptidase inhibitor, Kazal type 1; serine peptidase inhibitor, Kazal type 3; serine protease inhibitor Kazal-type 3; serine protease inhibitor Kazal-type 3-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_152936.1 → NP_690919.1 serine protease inhibitor Kazal-type 1-like precursor

See identical proteins and their annotated locations for NP_690919.1

Status: PROVISIONAL

Source sequence(s)

M27883

UniProtKB/Swiss-Prot

P09656

UniProtKB/TrEMBL

A6KUD6

Related

ENSRNOP00000112810.1, ENSRNOT00000155497.1

Conserved Domains (1) summary

cd01327
Location:35 → 79

KAZAL_PSTI; Kazal-type pancreatic secretory trypsin inhibitors (PSTI) and related proteins, including the second domain of the ovomucoid turkey inhibitor and the C-terminal domain of the esophagus cancer-related gene-2 protein (ECRG-2), are members of the ...