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    Slc45a3 solute carrier family 45, member 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304785, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc45a3provided by RGD
    Official Full Name
    solute carrier family 45, member 3provided by RGD
    Primary source
    RGD:1309764
    See related
    EnsemblRapid:ENSRNOG00000007591 AllianceGenome:RGD:1309764
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309764
    Summary
    Predicted to enable sucrose:proton symporter activity. Predicted to be involved in positive regulation of fatty acid biosynthetic process; positive regulation of glucose metabolic process; and regulation of oligodendrocyte differentiation. Predicted to act upstream of or within sucrose transport. Predicted to be active in membrane. Orthologous to human SLC45A3 (solute carrier family 45 member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 49.1), Spleen (RPKM 47.5) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc45a3 in Genome Data Viewer
    Location:
    13q13
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (45959467..45979763)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (43407293..43427588)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (48745855..48766283)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene nuclear casein kinase and cyclin-dependent kinase substrate 1 Neighboring gene RAN, member RAS oncogene family, pseudogene 4 Neighboring gene uncharacterized LOC134481494 Neighboring gene ETS transcription factor ELK4 Neighboring gene major facilitator superfamily domain containing 4A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. miR-32 and its target SLC45A3 regulate the lipid metabolism of oligodendrocytes and myelin. Shin D, et al. Neuroscience, 2012 Jun 28. PMID 22521588, Free PMC Article
    2. Proton-associated sucrose transport of mammalian solute carrier family 45: an analysis in Saccharomyces cerevisiae. Bartölke R, et al. Biochem J, 2014 Dec 1. PMID 25164149
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables sucrose:proton symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sucrose:proton symporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of glucose metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of oligodendrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within sucrose transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 45 member 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135868.2 → NP_001129340.1  solute carrier family 45 member 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A6IC37, D3ZPP5
      Related
      ENSRNOP00000010242.5, ENSRNOT00000010242.7
      Conserved Domains (1) summary
      cd17313
      Location:18 → 537
      MFS_SLC45_SUC; Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters

    2. NM_001430073.1 → NP_001417002.1  solute carrier family 45 member 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A6IC37, D3ZPP5

    3. NM_001430074.1 → NP_001417003.1  solute carrier family 45 member 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A6IC37, D3ZPP5

    4. NM_001430075.1 → NP_001417004.1  solute carrier family 45 member 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A6IC37, D3ZPP5

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      45959467..45979763
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006249765.5 → XP_006249827.1  solute carrier family 45 member 3 isoform X1

      Conserved Domains (1) summary
      cd17313
      Location:29 → 548
      MFS_SLC45_SUC; Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters

    2. XM_006249767.4 → XP_006249829.1  solute carrier family 45 member 3 isoform X1

      Conserved Domains (1) summary
      cd17313
      Location:29 → 548
      MFS_SLC45_SUC; Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters

    3. XM_006249766.4 → XP_006249828.1  solute carrier family 45 member 3 isoform X1

      Conserved Domains (1) summary
      cd17313
      Location:29 → 548
      MFS_SLC45_SUC; Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters
    Nucleotide Protein Strain
    Heading Accession and Version

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