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    Trappc12 trafficking protein particle complex subunit 12 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314013, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Trappc12provided by RGD
    Official Full Name
    trafficking protein particle complex subunit 12provided by RGD
    Primary source
    RGD:1566054
    See related
    EnsemblRapid:ENSRNOG00000009039 AllianceGenome:RGD:1566054
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ttc15; RGD1566054
    Summary
    Predicted to be involved in several processes, including endoplasmic reticulum to Golgi vesicle-mediated transport; positive regulation of protein localization to kinetochore; and regulation of kinetochore assembly. Predicted to be located in several cellular components, including endoplasmic reticulum-Golgi intermediate compartment; kinetochore; and perinuclear region of cytoplasm. Predicted to be part of TRAPP complex. Predicted to be active in Golgi apparatus. Orthologous to human TRAPPC12 (trafficking protein particle complex subunit 12). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 146.4), Heart (RPKM 137.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Trappc12 in Genome Data Viewer
    Location:
    6q16
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (51049878..51115343, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (45321496..45386967, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (47954822..48020280, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479353 Neighboring gene ribonuclease H1 Neighboring gene acireductone dioxygenase 1 Neighboring gene EARP complex and GARP complex interacting protein 1 Neighboring gene uncharacterized LOC102555103

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. TRAMM/TrappC12 plays a role in chromosome congression, kinetochore stability, and CENP-E recruitment. Milev MP, et al. J Cell Biol, 2015 Apr 27. PMID 25918224, Free PMC Article
    2. C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking. Scrivens PJ, et al. Mol Biol Cell, 2011 Jun 15. PMID 21525244, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in Golgi organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in metaphase chromosome alignment ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein localization to kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of kinetochore assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of TRAPP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of TRAPP complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    trafficking protein particle complex subunit 12
    Names
    tetratricopeptide repeat domain 15
    trafficking protein particle complex 12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398781.1 → NP_001385710.1  trafficking protein particle complex subunit 12

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6A729, D3ZE49
      Related
      ENSRNOP00000029577.5, ENSRNOT00000029859.9
      Conserved Domains (4) summary
      PHA03247
      Location:202 → 366
      PHA03247; large tegument protein UL36; Provisional
      TIGR02917
      Location:617 → 797
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:608 → 635
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:644 → 711
      TPR_12; Tetratricopeptide repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      51049878..51115343 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006239964.4 → XP_006240026.1  trafficking protein particle complex subunit 12 isoform X1

      See identical proteins and their annotated locations for XP_006240026.1

      UniProtKB/TrEMBL
      A0A8I6A729, D3ZE49
      Conserved Domains (4) summary
      PHA03247
      Location:202 → 366
      PHA03247; large tegument protein UL36; Provisional
      TIGR02917
      Location:617 → 797
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:608 → 635
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:644 → 711
      TPR_12; Tetratricopeptide repeat

    2. XM_063261896.1 → XP_063117966.1  trafficking protein particle complex subunit 12 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A729, D3ZE49
    Nucleotide Protein Strain
    Heading Accession and Version

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