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    Arsa arylsulfatase A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315222, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Arsaprovided by RGD
    Official Full Name
    arylsulfatase Aprovided by RGD
    Primary source
    RGD:1310381
    See related
    EnsemblRapid:ENSRNOG00000012953 AllianceGenome:RGD:1310381
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables arylsulfatase activity. Involved in several processes, including response to estrogen; response to ethanol; and response to methylmercury. Located in acrosomal vesicle; endosome; and extracellular space. Is extrinsic component of external side of plasma membrane. Used to study hypothyroidism. Human ortholog(s) of this gene implicated in metachromatic leukodystrophy. Orthologous to human ARSA (arylsulfatase A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 217.6), Kidney (RPKM 146.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Arsa in Genome Data Viewer
    Location:
    7q34
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (122422971..122426971, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (120542788..120547577, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (130446644..130452632, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479955 Neighboring gene choline kinase beta Neighboring gene uncharacterized LOC134479956 Neighboring gene mitogen-activated protein kinase 8 interacting protein 2 Neighboring gene uncharacterized LOC120093826 Neighboring gene SH3 and multiple ankyrin repeat domains 3 Neighboring gene uncharacterized LOC108351527

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Studies on urinary arylsulphatase activity in vitamin A deficient rats. Srinivas L, et al. Int J Vitam Nutr Res, 1976. PMID 4403
    2. Ethanol decreases rat hepatic arylsulfatase A activity levels. Jean S, et al. Alcohol Clin Exp Res, 2006 Nov. PMID 17067361
    3. Purification of rat liver arylsulfatase A and its microheterogeneity assayed by crossed affinity-immunoelectrophoresis. Wójczyk B, et al. Acta Biochim Pol, 1992. PMID 1363453
    4. Rat sperm AS-A: subcellular localization in testis and epididymis and surface distribution in epididymal sperm. Ngernsoungnern A, et al. Cell Tissue Res, 2004 Nov. PMID 15503159
    5. Hypothyroidism in the adult rat causes brain region-specific biochemical dysfunction. Ahmed MT, et al. J Endocrinol, 1993 Aug. PMID 7901316

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC125207

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables arylsulfatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables arylsulfatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cerebroside-sulfatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sulfuric ester hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagy IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within binding of sperm to zona pellucida ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to estrogen IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to ethanol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to methylmercury IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to nutrient IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to pH IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extrinsic component of external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    arylsulfatase A
    NP_001030105.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034933.3 → NP_001030105.2  arylsulfatase A precursor

      See identical proteins and their annotated locations for NP_001030105.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      F7FF93, Q32KK2, Q3KR80
      Related
      ENSRNOP00000017782.4, ENSRNOT00000017783.8
      Conserved Domains (2) summary
      COG3119
      Location:17 → 470
      AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
      cl23718
      Location:20 → 503
      ALP_like; alkaline phosphatases and sulfatases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      122422971..122426971 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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