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    Pla2g2d phospholipase A2, group IID [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298579, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pla2g2dprovided by RGD
    Official Full Name
    phospholipase A2, group IIDprovided by RGD
    Primary source
    RGD:1309862
    See related
    EnsemblRapid:ENSRNOG00000016826 AllianceGenome:RGD:1309862
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including calcium-dependent phospholipase A2 activity; heparan sulfate proteoglycan binding activity; and heparin binding activity. Predicted to be involved in glycerophospholipid metabolic process; negative regulation of T cell proliferation; and regulation of acute inflammatory response to antigenic stimulus. Predicted to act upstream of or within CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation and negative regulation of T cell activation. Predicted to be located in extracellular region. Orthologous to human PLA2G2D (phospholipase A2 group IID). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 252.0), Lung (RPKM 176.1) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pla2g2d in Genome Data Viewer
    Location:
    5q36
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (156299374..156305816)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (151016010..151022531)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (157222636..157228795)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene UBX domain protein 10 Neighboring gene phospholipase A2, group IIC Neighboring gene phospholipase A2, group IIF Neighboring gene phospholipase A2, group V Neighboring gene phospholipase A2 group IIA Neighboring gene phospholipase A2, group IIE

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Secretory phospholipase A2-IID is an effector molecule of CD4+CD25+ regulatory T cells. von Allmen CE, et al. Proc Natl Acad Sci U S A, 2009 Jul 14. PMID 19564598, Free PMC Article
    2. Structures, enzymatic properties, and expression of novel human and mouse secretory phospholipase A(2)s. Suzuki N, et al. J Biol Chem, 2000 Feb 25. PMID 10681567
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC108956

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent phospholipase A2 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent phospholipase A2 activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables heparan sulfate proteoglycan binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables heparin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in arachidonate secretion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of T cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of T cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylcholine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylcholine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylethanolamine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylglycerol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylglycerol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of acute inflammatory response to antigenic stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    group IID secretory phospholipase A2
    NP_001013446.1
    XP_038965606.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013428.2 → NP_001013446.1  group IID secretory phospholipase A2 precursor

      See identical proteins and their annotated locations for NP_001013446.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      F7F420, Q5BK35
      Related
      ENSRNOP00000112008.1, ENSRNOT00000130250.1
      Conserved Domains (1) summary
      cd00125
      Location:20 → 137
      PLA2c; Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a metal-dependent ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      156299374..156305816
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109678.2 → XP_038965606.1  group IID secretory phospholipase A2 isoform X1

      Related
      ENSRNOP00000022579.6, ENSRNOT00000022579.7
      Conserved Domains (1) summary
      cd00125
      Location:1 → 111
      PLA2c; Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a metal-dependent ...
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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