Tpr translocated promoter region, nuclear basket protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tprprovided by RGD
Official Full Name: translocated promoter region, nuclear basket proteinprovided by RGD
Primary source: RGD:1310664
See related: EnsemblRapid:ENSRNOG00000002394 AllianceGenome:RGD:1310664
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including dynein complex binding activity; mitogen-activated protein kinase binding activity; and protein homodimerization activity. Predicted to be a structural constituent of nuclear pore. Involved in positive regulation of protein export from nucleus and protein export from nucleus. Located in nuclear inclusion body; nuclear membrane; and nuclear periphery. Part of nuclear pore nuclear basket. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder. Orthologous to human TPR (translocated promoter region, nuclear basket protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 376.2), Spleen (RPKM 310.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q21

Exon count:: 52

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (64974419..65037604)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (62424312..62487502)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (67611685..67672833)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH144043 (e-PCR)
- UniSTS:233289

RH133437 (e-PCR)
- UniSTS:216720

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables dynein complex binding	IEA Inferred from Electronic Annotation more info
enables dynein complex binding	ISO Inferred from Sequence Orthology more info
enables heat shock protein binding	IEA Inferred from Electronic Annotation more info
enables heat shock protein binding	ISO Inferred from Sequence Orthology more info
enables heat shock protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables mitogen-activated protein kinase binding	IEA Inferred from Electronic Annotation more info
enables mitogen-activated protein kinase binding	ISO Inferred from Sequence Orthology more info
enables mitogen-activated protein kinase binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
NOT enables protein-membrane adaptor activity	ISO Inferred from Sequence Orthology more info
NOT enables protein-membrane adaptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables structural constituent of nuclear pore	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of nuclear pore	IEA Inferred from Electronic Annotation more info
enables structural constituent of nuclear pore	ISO Inferred from Sequence Orthology more info
enables structural constituent of nuclear pore	ISS Inferred from Sequence or Structural Similarity more info
enables tubulin binding	IEA Inferred from Electronic Annotation more info
enables tubulin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in RNA export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in RNA export from nucleus	ISS Inferred from Sequence or Structural Similarity more info
involved_in RNA import into nucleus	IEA Inferred from Electronic Annotation more info
involved_in RNA import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in RNA import into nucleus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in cellular response to heat	ISO Inferred from Sequence Orthology more info
involved_in cellular response to heat	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to interferon-alpha	IEA Inferred from Electronic Annotation more info
involved_in cellular response to interferon-alpha	ISO Inferred from Sequence Orthology more info
involved_in cellular response to interferon-alpha	ISS Inferred from Sequence or Structural Similarity more info
involved_in mRNA export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA export from nucleus in response to heat stress	IEA Inferred from Electronic Annotation more info
involved_in mRNA export from nucleus in response to heat stress	ISO Inferred from Sequence Orthology more info
involved_in mRNA export from nucleus in response to heat stress	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic spindle assembly checkpoint signaling	IEA Inferred from Electronic Annotation more info
involved_in mitotic spindle assembly checkpoint signaling	ISO Inferred from Sequence Orthology more info
involved_in mitotic spindle assembly checkpoint signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of RNA export from nucleus	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of RNA export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of RNA export from nucleus	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of translational initiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of translational initiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of translational initiation	ISS Inferred from Sequence or Structural Similarity more info
NOT involved_in nuclear matrix organization	ISO Inferred from Sequence Orthology more info
NOT involved_in nuclear matrix organization	ISS Inferred from Sequence or Structural Similarity more info
NOT involved_in nuclear pore complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in nuclear pore complex assembly	ISO Inferred from Sequence Orthology more info
involved_in nuclear pore organization	IEA Inferred from Electronic Annotation more info
NOT involved_in nuclear pore organization	ISO Inferred from Sequence Orthology more info
involved_in nuclear pore organization	ISO Inferred from Sequence Orthology more info
NOT involved_in nuclear pore organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of heterochromatin formation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of heterochromatin formation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of heterochromatin formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of intracellular protein transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intracellular protein transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of mitotic cell cycle spindle assembly checkpoint	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mitotic cell cycle spindle assembly checkpoint	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic cell cycle spindle assembly checkpoint	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein import into nucleus	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein import into nucleus	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in protein export from nucleus	ISO Inferred from Sequence Orthology more info
NOT involved_in protein export from nucleus	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein import into nucleus	IEA Inferred from Electronic Annotation more info
NOT involved_in protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in protein import into nucleus	ISO Inferred from Sequence Orthology more info
NOT involved_in protein import into nucleus	ISS Inferred from Sequence or Structural Similarity more info
NOT involved_in regulation of mRNA export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitotic sister chromatid separation	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitotic sister chromatid separation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of mitotic spindle assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mitotic spindle assembly	IEA Inferred from Electronic Annotation more info
involved_in regulation of mitotic spindle assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitotic spindle assembly	ISS Inferred from Sequence or Structural Similarity more info
NOT involved_in regulation of protein export from nucleus	ISO Inferred from Sequence Orthology more info
NOT involved_in regulation of protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in regulation of protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein localization	ISO Inferred from Sequence Orthology more info
NOT involved_in regulation of protein stability	ISO Inferred from Sequence Orthology more info
NOT involved_in regulation of protein stability	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to epidermal growth factor	IEA Inferred from Electronic Annotation more info
involved_in response to epidermal growth factor	ISO Inferred from Sequence Orthology more info
involved_in response to epidermal growth factor	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
part_of cytoplasmic dynein complex	IEA Inferred from Electronic Annotation more info
part_of cytoplasmic dynein complex	ISO Inferred from Sequence Orthology more info
part_of cytoplasmic dynein complex	ISS Inferred from Sequence or Structural Similarity more info
located_in kinetochore	IEA Inferred from Electronic Annotation more info
NOT located_in kinetochore	ISO Inferred from Sequence Orthology more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info
NOT located_in kinetochore	ISS Inferred from Sequence or Structural Similarity more info
located_in mitotic spindle	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear inclusion body	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear inclusion body	IEA Inferred from Electronic Annotation more info
located_in nuclear inclusion body	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear periphery	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear periphery	IEA Inferred from Electronic Annotation more info
located_in nuclear periphery	ISO Inferred from Sequence Orthology more info
part_of nuclear pore	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear pore	IEA Inferred from Electronic Annotation more info
part_of nuclear pore	ISO Inferred from Sequence Orthology more info
part_of nuclear pore	ISS Inferred from Sequence or Structural Similarity more info
part_of nuclear pore nuclear basket	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear pore nuclear basket	IEA Inferred from Electronic Annotation more info
part_of nuclear pore nuclear basket	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: nucleoprotein TPR

Names: NPC-associated intranuclear protein; megator; translocated promoter region (to activated MET oncogene); translocated promoter region protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107185.1 → NP_001100655.2 nucleoprotein TPR

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/Swiss-Prot

F1MA98, Q3T1J7

UniProtKB/TrEMBL

A0A8L2UNA6

Related

ENSRNOP00000062172.2, ENSRNOT00000063833.4

Conserved Domains (5) summary

COG1196
Location:109 → 852

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR04527
Location:1010 → 1106

mycoplas_twoTM; two transmembrane protein

pfam07926
Location:1094 → 1222

TPR_MLP1_2; TPR/MLP1/MLP2-like protein

pfam13166
Location:720 → 1120

AAA_13; AAA domain

cl12013
Location:282 → 428

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature