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    Ing1 inhibitor of growth family, member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306626, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ing1provided by RGD
    Official Full Name
    inhibitor of growth family, member 1provided by RGD
    Primary source
    RGD:1306330
    See related
    EnsemblRapid:ENSRNOG00000014520 AllianceGenome:RGD:1306330
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    p33ING1b; p33ING1c
    Summary
    Predicted to enable methylated histone binding activity. Predicted to be involved in positive regulation of DNA-templated transcription. Predicted to act upstream of or within protein import into nucleus and regulation of programmed cell death. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in head and neck squamous cell carcinoma and squamous cell carcinoma. Orthologous to human ING1 (inhibitor of growth family member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See Ing1 in Genome Data Viewer
    Location:
    16q12.5
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (84639378..84649498, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (77937276..77945320, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (83277055..83278120, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene Rho guanine nucleotide exchange factor 7 Neighboring gene uncharacterized LOC134482534 Neighboring gene uncharacterized LOC120097568 Neighboring gene ankyrin repeat domain 10 Neighboring gene uncharacterized LOC134482536 Neighboring gene cysteinyl-tRNA synthetase 2, mitochondrial Neighboring gene NAD(P)HX dehydratase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of nuclear localization signal in mouse ING1 homolog protein. Ha S, et al. Biochem Biophys Res Commun, 2002 Apr 26. PMID 12054579
    2. Genomic structure of the human ING1 gene and tumor-specific mutations detected in head and neck squamous cell carcinomas. Gunduz M, et al. Cancer Res, 2000 Jun 15. PMID 10866301
    3. Tollip is a mediator of protein sumoylation. Ciarrocchi A, et al. PLoS One, 2009. PMID 19198660, Free PMC Article
    4. ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression. Shi X, et al. Nature, 2006 Jul 6. PMID 16728974, Free PMC Article
    5. SEI family of nuclear factors regulates p53-dependent transcriptional activation. Watanabe-Fukunaga R, et al. Genes Cells, 2005 Aug. PMID 16098148

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methylated histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of programmed cell death ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    inhibitor of growth protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001038591.2 → NP_001033680.2  inhibitor of growth protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      B2GVA7, Q2TSE3
      Related
      ENSRNOP00000109765.1, ENSRNOT00000167372.1

    2. NM_001433921.1 → NP_001420850.1  inhibitor of growth protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      Q2TSE3

    3. NM_001433922.1 → NP_001420851.1  inhibitor of growth protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A6IWP1, G3V7V1, Q2TSE1

    4. NM_001433923.1 → NP_001420852.1  inhibitor of growth protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A6IWP1, G3V7V1, Q2TSE1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      84639378..84649498 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039094601.2 → XP_038950529.1  inhibitor of growth protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZM05
      Related
      ENSRNOP00000112064.1, ENSRNOT00000167154.1
      Conserved Domains (2) summary
      cd15584
      Location:329 → 373
      PHD_ING1_2; PHD finger found in inhibitor of growth protein 1 (ING1) and 2 (ING2)
      cl28919
      Location:162 → 224
      ING; Inhibitor of growth (ING) domain family

    2. XM_039094602.2 → XP_038950530.1  inhibitor of growth protein 1 isoform X2

      UniProtKB/TrEMBL
      A6IWP1, G3V7V1, Q2TSE1
      Related
      ENSRNOP00000079627.2, ENSRNOT00000120249.2
      Conserved Domains (2) summary
      COG5034
      Location:37 → 163
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15584
      Location:118 → 162
      PHD_ING1_2; PHD finger found in inhibitor of growth protein 1 (ING1) and 2 (ING2)
    Nucleotide Protein Strain
    Heading Accession and Version

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