Prkx protein kinase cAMP-dependent X-linked catalytic subunit [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Prkxprovided by RGD
Official Full Name: protein kinase cAMP-dependent X-linked catalytic subunitprovided by RGD
Primary source: RGD:1564076
See related: EnsemblRapid:ENSRNOG00000060168 AllianceGenome:RGD:1564076
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable cAMP-dependent protein kinase activity. Predicted to be involved in several processes, including endothelial cell proliferation; protein phosphorylation; and tube morphogenesis. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of cAMP-dependent protein kinase complex. Predicted to be active in cytosol. Orthologous to several human genes including PRKX (protein kinase cAMP-dependent X-linked catalytic subunit). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 72.7), Thymus (RPKM 62.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq21

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (45701747..45745210, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (41823349..41866844, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (45080963..45125095, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH127732 (e-PCR)
- UniSTS:211042

BQ195742 (e-PCR)
- UniSTS:260592

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables cAMP-dependent protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cAMP-dependent protein kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell-substrate adhesion	ISO Inferred from Sequence Orthology more info
involved_in endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in epithelial tube morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in kidney morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in myeloid cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of epithelial cell differentiation involved in kidney development	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of cAMP-dependent protein kinase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cAMP-dependent protein kinase catalytic subunit PRKX

Names: protein kinase, X-linked; serine/threonine-protein kinase PRKX

NP_001029135.1

EC 2.7.11.1

XP_017457623.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033963.2 → NP_001029135.1 cAMP-dependent protein kinase catalytic subunit PRKX

See identical proteins and their annotated locations for NP_001029135.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000021

UniProtKB/TrEMBL

Q5BK52

Conserved Domains (2) summary

PTZ00263
Location:35 → 358

PTZ00263; protein kinase A catalytic subunit; Provisional

cd05612
Location:47 → 338

STKc_PRKX_like; Catalytic domain of PRKX-like Protein Serine/Threonine Kinases