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    Siah2 siah E3 ubiquitin protein ligase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 140593, updated on 9-Dec-2024

    Summary

    Official Symbol
    Siah2provided by RGD
    Official Full Name
    siah E3 ubiquitin protein ligase 2provided by RGD
    Primary source
    RGD:620778
    See related
    EnsemblRapid:ENSRNOG00000013703 AllianceGenome:RGD:620778
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables ubiquitin conjugating enzyme binding activity. Involved in regulation of protein ubiquitination. Located in early endosome and neuronal cell body. Orthologous to human SIAH2 (siah E3 ubiquitin protein ligase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 41.9), Spleen (RPKM 41.6) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Siah2 in Genome Data Viewer
    Location:
    2q26
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (145063847..145081675, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (142913924..142931752, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (148874151..148891900, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene selenoprotein T Neighboring gene glutamate-rich 6 Neighboring gene uncharacterized LOC134485621 Neighboring gene MINDY family member 4B Neighboring gene clarin 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein binding PubMed 
    enables transferase activity  
    enables ubiquitin conjugating enzyme binding  
    enables ubiquitin conjugating enzyme binding PubMed 
    enables ubiquitin protein ligase activity  
    enables ubiquitin protein ligase activity  
    enables ubiquitin protein ligase activity  
    enables ubiquitin-protein transferase activity  
    enables ubiquitin-protein transferase activity  
    enables ubiquitin-protein transferase activity PubMed 
    enables zinc ion binding  
    Process Evidence Code Pubs
    involved_in apoptotic process  
    involved_in canonical Wnt signaling pathway  
    involved_in negative regulation of apoptotic process  
    acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway  
    involved_in negative regulation of cysteine-type endopeptidase activity  
    involved_in negative regulation of extrinsic apoptotic signaling pathway  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process  
    involved_in protein ubiquitination  
    involved_in regulation of circadian rhythm  
    involved_in regulation of circadian rhythm  
    involved_in regulation of protein ubiquitination PubMed 
    involved_in rhythmic process  
    involved_in ubiquitin-dependent protein catabolic process  
    involved_in ubiquitin-dependent protein catabolic process  
    involved_in ubiquitin-dependent protein catabolic process  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol  
    located_in early endosome PubMed 
    located_in intracellular membrane-bounded organelle  
    located_in neuronal cell body PubMed 
    located_in nucleoplasm  
    located_in nucleoplasm  

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase SIAH2
    Names
    RING-type E3 ubiquitin transferase SIAH2
    seven in absentia 2
    seven in absentia homolog 2
    siah-2
    NP_604452.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_134457.2NP_604452.1  E3 ubiquitin-protein ligase SIAH2

      See identical proteins and their annotated locations for NP_604452.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      Q8R4T2, Q920M8
      UniProtKB/TrEMBL
      A6JVJ3
      Related
      ENSRNOP00000018488.1, ENSRNOT00000018488.4
      Conserved Domains (2) summary
      cd16752
      Location:79116
      RING-HC_SIAH2; RING finger, HC subclass, found in seven in absentia homolog 2 (SIAH2) and similar proteins
      pfam03145
      Location:123319
      Sina; Seven in absentia protein family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      145063847..145081675 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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