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    Kif15 kinesin family member 15 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 353302, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kif15provided by RGD
    Official Full Name
    kinesin family member 15provided by RGD
    Primary source
    RGD:727790
    See related
    EnsemblRapid:ENSRNOG00000060356 AllianceGenome:RGD:727790
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Knsl7
    Summary
    Predicted to enable ATP hydrolysis activity; microtubule binding activity; and plus-end-directed microtubule motor activity. Predicted to be involved in centrosome separation; microtubule-based movement; and mitotic spindle assembly. Predicted to be located in spindle pole. Predicted to be part of kinesin complex. Predicted to be active in cytoplasm and microtubule. Orthologous to human KIF15 (kinesin family member 15). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 138.5), Spleen (RPKM 70.0) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kif15 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (131479340..131550209)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (122601888..122672750)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (132033117..132103528)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein A1, pseudogene 36 Neighboring gene similar to RIKEN cDNA 1110059G10 Neighboring gene ribosomal protein L7, pseudogene 3 Neighboring gene transmembrane protein 42 Neighboring gene transglutaminase 4 Neighboring gene zinc finger DHHC-type palmitoyltransferase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. KIF15 supports spermatogenesis via its effects on Sertoli cell microtubule, actin, vimentin, and septin cytoskeletons. Wu S, et al. Endocrinology, 2021 Apr 1. PMID 33453102, Free PMC Article
    2. Depletion of kinesin-12, a myosin-IIB-interacting protein, promotes migration of cortical astrocytes. Feng J, et al. J Cell Sci, 2016 Jun 15. PMID 27170353, Free PMC Article
    3. Kinesin-12, a mitotic microtubule-associated motor protein, impacts axonal growth, navigation, and branching. Liu M, et al. J Neurosci, 2010 Nov 3. PMID 21048148, Free PMC Article
    4. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. KIF15 supports spermatogenesis via its effects on Sertoli cell microtubule, actin, vimentin, and septin cytoskeletons.
      Title: KIF15 supports spermatogenesis via its effects on Sertoli cell microtubule, actin, vimentin, and septin cytoskeletons.
    2. kinesin-12 depletion from cultured rat cortical astrocytes decreases cell proliferation but increases migration.
      Title: Depletion of kinesin-12, a myosin-IIB-interacting protein, promotes migration of cortical astrocytes.
    3. Kinesin-12 shares functions with kinesin-5 related to microtubule-microtubule interactions, but kinesin-12 has other functions not shared by kinesin-5 that are related to the ability of kinesin-12 to interact with actin.
      Title: Kinesin-12, a mitotic microtubule-associated motor protein, impacts axonal growth, navigation, and branching.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables plus-end-directed microtubule motor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in centrosome separation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic spindle assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle pole ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    kinesin-like protein KIF15
    Names
    kinesin-like 7
    kinesin-like protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_181635.2 → NP_853666.1  kinesin-like protein KIF15

      See identical proteins and their annotated locations for NP_853666.1

      Status: PROVISIONAL

      Source sequence(s)
      AY291580
      UniProtKB/Swiss-Prot
      Q7TN17, Q7TSP2
      Related
      ENSRNOP00000071501.1, ENSRNOT00000089278.3
      Conserved Domains (6) summary
      smart00129
      Location:26 → 370
      KISc; Kinesin motor, catalytic domain. ATPase
      PRK03918
      Location:426 → 970
      PRK03918; chromosome segregation protein; Provisional
      TIGR02168
      Location:704 → 1375
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd01373
      Location:25 → 373
      KISc_KLP2_like; Kinesin motor domain, KIF15-like subgroup
      pfam12711
      Location:463 → 551
      Kinesin-relat_1; Kinesin motor
      pfam15908
      Location:1256 → 1385
      HMMR_C; Hyaluronan mediated motility receptor C-terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      131479340..131550209
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039081674.2 → XP_038937602.1  kinesin-like protein KIF15 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K0M1, A6I495
      Related
      ENSRNOP00000084732.1, ENSRNOT00000096660.2
      Conserved Domains (3) summary
      COG0419
      Location:876 → 1396
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:361 → 1126
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01373
      Location:25 → 373
      KISc_KLP2_like; Kinesin motor domain, KIF15-like subgroup

    2. XM_039081678.2 → XP_038937606.1  kinesin-like protein KIF15 isoform X4

      Conserved Domains (2) summary
      COG1196
      Location:395 → 749
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01373
      Location:25 → 373
      KISc_KLP2_like; Kinesin motor domain, KIF15-like subgroup

    3. XM_039081679.2 → XP_038937607.1  kinesin-like protein KIF15 isoform X5

      Conserved Domains (2) summary
      COG1196
      Location:395 → 749
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01373
      Location:25 → 373
      KISc_KLP2_like; Kinesin motor domain, KIF15-like subgroup

    4. XM_039081680.2 → XP_038937608.1  kinesin-like protein KIF15 isoform X6

      Conserved Domains (2) summary
      COG1196
      Location:395 → 749
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01373
      Location:25 → 373
      KISc_KLP2_like; Kinesin motor domain, KIF15-like subgroup

    5. XM_039081677.2 → XP_038937605.1  kinesin-like protein KIF15 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K0M1, A6I495
      Conserved Domains (3) summary
      PTZ00121
      Location:816 → 1299
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:264 → 1039
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl22853
      Location:1 → 276
      Motor_domain; Myosin and Kinesin motor domain

    6. XM_039081675.2 → XP_038937603.1  kinesin-like protein KIF15 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K0M1, A6I495
      Conserved Domains (3) summary
      PTZ00121
      Location:836 → 1319
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:284 → 1059
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01373
      Location:2 → 296
      KISc_KLP2_like; Kinesin motor domain, KIF15-like subgroup

    7. XM_039081676.2 → XP_038937604.1  kinesin-like protein KIF15 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K0M1, A6I495
      Conserved Domains (3) summary
      PTZ00121
      Location:836 → 1319
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:284 → 1059
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01373
      Location:2 → 296
      KISc_KLP2_like; Kinesin motor domain, KIF15-like subgroup

    RNA

    1. XR_010053989.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TSP2.1 GenPept UniProtKB/Swiss-Prot:Q7TSP2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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