Tas1r2 taste 1 receptor member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Gene symbol: Tas1r2
Gene description: taste 1 receptor member 2
See related: EnsemblRapid:ENSRNOG00000061876
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tr2; T1r2; Gpr71; Aldh4a1
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (157192799..157208937)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (151909617..151925760)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (158119894..158135733)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Maternal high-fat diet during gestation and lactation increases conditioned aversion threshold for sucrose and alters sweet taste receptors expression in taste buds in rat offspring.
Title: Maternal high-fat diet during gestation and lactation increases conditioned aversion threshold for sucrose and alters sweet taste receptors expression in taste buds in rat offspring.
Sweet taste molecules of T1R2, T1R3, alpha-gustducin and TRPM5 in ileum were dramatically higher than those in duodenum (P<0.01 for each).
Title: Expression of sweet taste receptor and gut hormone secretion in modelled type 2 diabetes.
A subset of synaptogyrin-1-immunoreactive taste cells also expressed phospholipase Cbeta2, gustducin, or sweet taste receptor (T1R2).
Title: Expression of synaptogyrin-1 in T1R2-expressing type II taste cells and type III taste cells of rat circumvallate taste buds.

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General gene information

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General protein information

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Preferred Names: taste receptor type 1 member 2

Names: G protein-coupled receptor 71; aldehyde dehydrogenase 4 family, member A1; sweet taste receptor T1R2; taste receptor TR2; taste receptor, type 1, member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001271266.2 → NP_001258195.1 taste receptor type 1 member 2 precursor

See identical proteins and their annotated locations for NP_001258195.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

Q9Z0R7

UniProtKB/TrEMBL

A0A8I6A130

Related

ENSRNOP00000072481.1, ENSRNOT00000077863.3

Conserved Domains (4) summary

pfam07562
Location:495 → 548

NCD3G; Nine Cysteines Domain of family 3 GPCR

cd14964
Location:569 → 593

7tm_GPCRs; TM helix 1 [structural motif]

cl10011
Location:30 → 495

Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily

cl28897
Location:569 → 821

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily