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    B3gnt8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308440, updated on 9-Dec-2024

    Summary

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    Official Symbol
    B3gnt8provided by RGD
    Official Full Name
    UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8provided by RGD
    Primary source
    RGD:1305374
    See related
    EnsemblRapid:ENSRNOG00000068024 AllianceGenome:RGD:1305374
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    B3galt7
    Summary
    Predicted to enable protein N-acetylglucosaminyltransferase activity. Predicted to be involved in poly-N-acetyllactosamine biosynthetic process and protein O-linked glycosylation. Predicted to be active in Golgi membrane. Orthologous to human B3GNT8 (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 15.8), Heart (RPKM 14.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See B3gnt8 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (90263387..90266292)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (81135602..81138501)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (82419264..82422852)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102549342 Neighboring gene CEA cell adhesion molecule 1 Neighboring gene glutamate-rich 4 Neighboring gene distal membrane arm assembly component 2 Neighboring gene branched chain keto acid dehydrogenase E1 subunit alpha Neighboring gene exosome component 5 Neighboring gene transmembrane protein 91

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A novel beta1,3-N-acetylglucosaminyltransferase (beta3Gn-T8), which synthesizes poly-N-acetyllactosamine, is dramatically upregulated in colon cancer. Ishida H, et al. FEBS Lett, 2005 Jan 3. PMID 15620693
    2. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein N-acetylglucosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein N-acetylglucosaminyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in poly-N-acetyllactosamine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in poly-N-acetyllactosamine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein O-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8
    Names
    UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107492.1 → NP_001100962.1  UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8

      See identical proteins and their annotated locations for NP_001100962.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473979
      UniProtKB/TrEMBL
      A6J972, D3ZE36
      Conserved Domains (1) summary
      cl21608
      Location:154 → 341
      Galactosyl_T; Galactosyltransferase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      90263387..90266292
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006228434.5 → XP_006228496.1  UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 isoform X1

      See identical proteins and their annotated locations for XP_006228496.1

      UniProtKB/TrEMBL
      A6J972, D3ZE36
      Related
      ENSRNOP00000083186.1, ENSRNOT00000104230.2
      Conserved Domains (1) summary
      cl21608
      Location:154 → 341
      Galactosyl_T; Galactosyltransferase

    2. XM_063261364.1 → XP_063117434.1  UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 isoform X1

      UniProtKB/TrEMBL
      A6J972, D3ZE36
      Related
      ENSRNOP00000109412.1, ENSRNOT00000156740.1
    Nucleotide Protein Strain
    Heading Accession and Version

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