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    Lrig2 leucine-rich repeats and immunoglobulin-like domains 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310753, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lrig2provided by RGD
    Official Full Name
    leucine-rich repeats and immunoglobulin-like domains 2provided by RGD
    Primary source
    RGD:1309554
    See related
    EnsemblRapid:ENSRNOG00000019957 AllianceGenome:RGD:1309554
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable signaling receptor binding activity. Predicted to act upstream of or within several processes, including negative regulation of axon regeneration; negative regulation of membrane protein ectodomain proteolysis; and positive regulation of protein localization to cell surface. Predicted to be located in growth cone; intracellular vesicle; and membrane. Predicted to be active in extracellular matrix and extracellular space. Human ortholog(s) of this gene implicated in urofacial syndrome. Orthologous to human LRIG2 (leucine rich repeats and immunoglobulin like domains 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 109.1), Brain (RPKM 107.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lrig2 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (194635686..194705014, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (191947322..192012996, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (206928708..206997915, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103691658 Neighboring gene ribosomal protein lateral stalk subunit P0 like 1 Neighboring gene U6 spliceosomal RNA Neighboring gene transfer RNA leucine (anticodon AAG) 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Lrig2-deficient mice are protected against PDGFB-induced glioma. Rondahl V, et al. PLoS One, 2013. PMID 24023893, Free PMC Article
    2. In vivo analysis of Lrig genes reveals redundant and independent functions in the inner ear. Del Rio T, et al. PLoS Genet, 2013. PMID 24086156, Free PMC Article
    3. Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases. van Erp S, et al. Dev Cell, 2015 Dec 7. PMID 26651291
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within innervation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of membrane protein ectodomain proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of axon regeneration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of membrane protein ectodomain proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of protein localization to cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of protein localization to cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of axon regeneration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of neuron migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of platelet-derived growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within sensory perception of sound ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in growth cone ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeats and immunoglobulin-like domains protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107710.1 → NP_001101180.1  leucine-rich repeats and immunoglobulin-like domains protein 2 precursor

      See identical proteins and their annotated locations for NP_001101180.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474015
      UniProtKB/TrEMBL
      A6K3N9, D3ZQV2
      Related
      ENSRNOP00000027042.5, ENSRNOT00000027042.7
      Conserved Domains (9) summary
      cd05763
      Location:618 → 692
      Ig_1; Subgroup of the immunoglobulin (Ig) superfamily
      smart00082
      Location:444 → 492
      LRRCT; Leucine rich repeat C-terminal domain
      smart00409
      Location:503 → 597
      IG; Immunoglobulin
      cd00116
      Location:136 → 398
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam07679
      Location:601 → 691
      I-set; Immunoglobulin I-set domain
      sd00033
      Location:145 → 167
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:385 → 426
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:311 → 370
      LRR_8; Leucine rich repeat
      cl11960
      Location:713 → 782
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      194635686..194705014 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017590916.3 → XP_017446405.1  leucine-rich repeats and immunoglobulin-like domains protein 2 isoform X2

      Related
      ENSRNOP00000105196.1, ENSRNOT00000123621.1

    2. XM_006233083.5 → XP_006233145.1  leucine-rich repeats and immunoglobulin-like domains protein 2 isoform X1

      Conserved Domains (9) summary
      cd05763
      Location:618 → 692
      Ig_1; Subgroup of the immunoglobulin (Ig) superfamily
      smart00082
      Location:444 → 492
      LRRCT; Leucine rich repeat C-terminal domain
      smart00409
      Location:503 → 597
      IG; Immunoglobulin
      cd00116
      Location:136 → 398
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam07679
      Location:601 → 691
      I-set; Immunoglobulin I-set domain
      sd00033
      Location:145 → 167
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:385 → 426
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:311 → 370
      LRR_8; Leucine rich repeat
      cl11960
      Location:713 → 782
      Ig; Immunoglobulin domain

    3. XM_039102415.2 → XP_038958343.1  leucine-rich repeats and immunoglobulin-like domains protein 2 isoform X3

      Conserved Domains (7) summary
      smart00082
      Location:444 → 492
      LRRCT; Leucine rich repeat C-terminal domain
      COG4886
      Location:117 → 463
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:145 → 167
      LRR_RI; leucine-rich repeat [structural motif]
      pfam07679
      Location:695 → 782
      I-set; Immunoglobulin I-set domain
      pfam13927
      Location:496 → 583
      Ig_3; Immunoglobulin domain
      cd00096
      Location:703 → 706
      Ig; Ig strand A' [structural motif]
      cd05763
      Location:602 → 692
      IgI_LRIG1-like; Immunoglobulin (Ig)-like ectodomain of the LRIG1 (Leucine-rich Repeats And Immunoglobulin-like Domains Protein 1) and similar proteins; member of the I-set of IgSF domains
    Nucleotide Protein Strain
    Heading Accession and Version

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