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    Sh3bp4 SH3-domain binding protein 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64634, updated on 9-Dec-2024

    Summary

    Symbol
    Sh3bp4provided by RGD
    Full Name
    SH3-domain binding protein 4provided by RGD
    Primary source
    RGD:620219
    See related
    EnsemblRapid:ENSRNOG00000019316 AllianceGenome:RGD:620219
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GDP-dissociation inhibitor activity; identical protein binding activity; and small GTPase binding activity. Predicted to be involved in several processes, including negative regulation of GTPase activity; negative regulation of TOR signaling; and protein localization to lysosome. Predicted to be located in clathrin-coated pit; clathrin-coated vesicle; and nucleus. Predicted to be active in cytoplasm. Orthologous to human SH3BP4 (SH3 domain binding protein 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 124.5), Kidney (RPKM 81.6) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Sh3bp4 in Genome Data Viewer
    Location:
    9q35
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (97107877..97186878)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (89660156..89739163)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (96210750..96288903)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene Glyceraldehyde-3-phosphate dehydrogenase, pseudogene 25 Neighboring gene uncharacterized LOC120094740 Neighboring gene uncharacterized LOC134480405 Neighboring gene uncharacterized LOC134480406 Neighboring gene uncharacterized LOC102554430 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GDP-dissociation inhibitor activity  
    enables GDP-dissociation inhibitor activity  
    enables GDP-dissociation inhibitor activity  
    enables identical protein binding  
    enables identical protein binding  
    enables small GTPase binding  
    enables small GTPase binding  
    Process Evidence Code Pubs
    NOT involved_in amino acid import  
    involved_in cellular response to amino acid stimulus  
    involved_in cellular response to amino acid stimulus  
    involved_in cellular response to amino acid stimulus  
    involved_in endocytosis  
    involved_in negative regulation of GTPase activity  
    involved_in negative regulation of GTPase activity  
    involved_in negative regulation of TOR signaling  
    involved_in negative regulation of TOR signaling  
    involved_in negative regulation of TOR signaling  
    involved_in negative regulation of cell growth  
    involved_in negative regulation of cell growth  
    involved_in negative regulation of cell growth  
    involved_in negative regulation of cell population proliferation  
    involved_in negative regulation of cell population proliferation  
    involved_in negative regulation of cell population proliferation  
    involved_in positive regulation of autophagy  
    involved_in positive regulation of autophagy  
    involved_in positive regulation of autophagy  
    involved_in protein localization to lysosome  
    involved_in protein localization to lysosome  
    involved_in protein localization to lysosome  
    involved_in regulation of catalytic activity  
    involved_in regulation of catalytic activity  
    Component Evidence Code Pubs
    located_in clathrin-coated pit  
    located_in clathrin-coated vesicle  
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in nucleus  

    General protein information

    Preferred Names
    SH3 domain-binding protein 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022693.4NP_073184.3  SH3 domain-binding protein 4

      See identical proteins and their annotated locations for NP_073184.3

      Status: VALIDATED

      Source sequence(s)
      FM034920, JAXUCZ010000009
      UniProtKB/Swiss-Prot
      Q9JJS5
      UniProtKB/TrEMBL
      A6JQK2, G3V8J0
      Related
      ENSRNOP00000026312.2, ENSRNOT00000026312.6
      Conserved Domains (3) summary
      cd11757
      Location:59110
      SH3_SH3BP4; Src Homology 3 domain of SH3 domain-binding protein 4
      pfam07653
      Location:656720
      SH3_2; Variant SH3 domain
      cl02517
      Location:322402
      ZU5; ZU5 domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      97107877..97186878
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039084182.2XP_038940110.1  SH3 domain-binding protein 4 isoform X1

      UniProtKB/Swiss-Prot
      Q9JJS5
      Conserved Domains (3) summary
      cd11757
      Location:59110
      SH3_SH3BP4; Src Homology 3 domain of SH3 domain-binding protein 4
      pfam07653
      Location:656717
      SH3_2; Variant SH3 domain
      cl02517
      Location:322402
      ZU5; ZU5 domain
    2. XM_039084183.2XP_038940111.1  SH3 domain-binding protein 4 isoform X1

      UniProtKB/Swiss-Prot
      Q9JJS5
      Conserved Domains (3) summary
      cd11757
      Location:59110
      SH3_SH3BP4; Src Homology 3 domain of SH3 domain-binding protein 4
      pfam07653
      Location:656717
      SH3_2; Variant SH3 domain
      cl02517
      Location:322402
      ZU5; ZU5 domain
    3. XM_008767298.4XP_008765520.1  SH3 domain-binding protein 4 isoform X2

      See identical proteins and their annotated locations for XP_008765520.1

      UniProtKB/Swiss-Prot
      Q9JJS5
      UniProtKB/TrEMBL
      A6JQK2, G3V8J0
      Conserved Domains (3) summary
      cd11757
      Location:59110
      SH3_SH3BP4; Src Homology 3 domain of SH3 domain-binding protein 4
      pfam07653
      Location:656720
      SH3_2; Variant SH3 domain
      cl02517
      Location:322402
      ZU5; ZU5 domain
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