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    Rrm2b ribonucleotide reductase regulatory TP53 inducible subunit M2B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299976, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rrm2bprovided by RGD
    Official Full Name
    ribonucleotide reductase regulatory TP53 inducible subunit M2Bprovided by RGD
    Primary source
    RGD:1306045
    See related
    EnsemblRapid:ENSRNOG00000025454 AllianceGenome:RGD:1306045
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity and ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Involved in response to amine. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 5; mitochondrial DNA depletion syndrome 8a; and mitochondrial DNA depletion syndrome 8b. Orthologous to human RRM2B (ribonucleotide reductase regulatory TP53 inducible subunit M2B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 120.9), Kidney (RPKM 112.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rrm2b in Genome Data Viewer
    Location:
    7q22
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (70962008..70993726, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (69077024..69108742, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (76750045..76780817, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene neurocalcin delta Neighboring gene uncharacterized LOC120093633 Neighboring gene uncharacterized LOC134479713 Neighboring gene uncharacterized LOC120093634 Neighboring gene ubiquitin protein ligase E3 component n-recognin 5 Neighboring gene poly(A) polymerase beta, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Strong induction of p73 protein in vivo coincides with the onset of apoptosis in rat liver after treatment with the hepatocarcinogen N-nitrosomorpholine (NNM). Tudzarova-Trajkovska S, et al. J Cell Biochem, 2003 Nov 1. PMID 14587038
    2. Impaired function of p53R2 in Rrm2b-null mice causes severe renal failure through attenuation of dNTP pools. Kimura T, et al. Nat Genet, 2003 Aug. PMID 12858174
    3. Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion. Bourdon A, et al. Nat Genet, 2007 Jun. PMID 17486094
    4. Mammalian p53R2 protein forms an active ribonucleotide reductase in vitro with the R1 protein, which is expressed both in resting cells in response to DNA damage and in proliferating cells. Guittet O, et al. J Biol Chem, 2001 Nov 2. PMID 11517226
    5. A massively parallel pipeline to clone DNA variants and examine molecular phenotypes of human disease mutations. Wei X, et al. PLoS Genet, 2014 Dec. PMID 25502805, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in 2'-deoxyribonucleotide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within DNA repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within deoxyribonucleoside triphosphate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in deoxyribonucleotide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within deoxyribonucleotide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within kidney development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within mitochondrial DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of G0 to G1 transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within renal system process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to amine IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribonucleoside diphosphate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ribonucleoside-diphosphate reductase subunit M2 B
    Names
    ribonucleotide reductase M2 B (TP53 inducible)
    NP_001124015.1
    XP_038934729.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130543.1 → NP_001124015.1  ribonucleoside-diphosphate reductase subunit M2 B

      See identical proteins and their annotated locations for NP_001124015.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473950
      UniProtKB/TrEMBL
      A6HR51, D4ADQ1
      Related
      ENSRNOP00000038047.6, ENSRNOT00000033704.8
      Conserved Domains (1) summary
      cl00264
      Location:32 → 351
      Ferritin_like; Ferritin-like superfamily of diiron-containing four-helix-bundle proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      70962008..70993726 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078801.2 → XP_038934729.1  ribonucleoside-diphosphate reductase subunit M2 B isoform X1

      UniProtKB/TrEMBL
      A0A8I6ACU7
      Related
      ENSRNOP00000090940.1, ENSRNOT00000107052.2
      Conserved Domains (1) summary
      cl00264
      Location:16 → 299
      Ferritin_like; Ferritin-like superfamily of diiron-containing four-helix-bundle proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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