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    Psip1 PC4 and SRSF1 interacting protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313323, updated on 9-Dec-2024

    Summary

    Official Symbol
    Psip1provided by RGD
    Official Full Name
    PC4 and SRSF1 interacting protein 1provided by RGD
    Primary source
    RGD:631439
    See related
    EnsemblRapid:ENSRNOG00000011498 AllianceGenome:RGD:631439
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ledgf; Psip2; SBP75
    Summary
    Enables supercoiled DNA binding activity. Predicted to be involved in several processes, including mRNA 5'-splice site recognition; positive regulation of transcription by RNA polymerase II; and response to heat. Located in euchromatin and heterochromatin. Orthologous to human PSIP1 (PC4 and SRSF1 interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 360.6), Brain (RPKM 288.2) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Psip1 in Genome Data Viewer
    Location:
    5q31
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (102892929..102925191, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (97847010..97879280, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (101555691..101588659, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene NSA2 ribosome biogenesis factor, pseudogene 12 Neighboring gene small nuclear RNA activating complex, polypeptide 3 Neighboring gene PC4 and SRSF1 interacting protein 1 like Neighboring gene coiled-coil domain containing 171 Neighboring gene ladinin-1-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding  
    enables DNA-binding transcription factor binding  
    enables DNA-binding transcription factor binding  
    enables chromatin binding  
    enables chromatin binding  
    enables supercoiled DNA binding PubMed 
    enables transcription coactivator activity  
    enables transcription coactivator activity  
    Process Evidence Code Pubs
    involved_in chromatin remodeling  
    involved_in mRNA 5'-splice site recognition  
    involved_in mRNA 5'-splice site recognition  
    involved_in mRNA 5'-splice site recognition  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in response to heat  
    involved_in response to heat  
    involved_in response to heat  
    involved_in response to oxidative stress  
    involved_in response to oxidative stress  
    involved_in response to oxidative stress  
    Component Evidence Code Pubs
    located_in euchromatin PubMed 
    located_in heterochromatin PubMed 
    located_in heterochromatin  
    located_in heterochromatin  
    located_in nuclear periphery  
    located_in nuclear periphery  
    NOT located_in nucleolus PubMed 
    NOT located_in nucleolus  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus  
    located_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    PC4 and SFRS1-interacting protein
    Names
    PC4 and SFRS1 interacting protein 1
    PC4 and SFRS1 interacting protein 2
    lens epithelium-derived growth factor
    supercoiled DNA binding protein 75

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175765.2NP_786941.1  PC4 and SFRS1-interacting protein

      See identical proteins and their annotated locations for NP_786941.1

      Status: PROVISIONAL

      Source sequence(s)
      AF339084
      UniProtKB/Swiss-Prot
      Q7TNY0, Q812D1
      UniProtKB/TrEMBL
      A0A8I5Y7G7
      Related
      ENSRNOP00000077371.1, ENSRNOT00000094774.2
      Conserved Domains (2) summary
      cd05834
      Location:387
      HDGF_related; The PWWP domain is an essential part of the Hepatoma Derived Growth Factor (HDGF) family of proteins, and is necessary for DNA binding by HDGF. This family of endogenous nuclear-targeted mitogens includes HRP (HDGF-related proteins 1, 2, 3, 4, or HPR1, ...
      pfam11467
      Location:347448
      LEDGF; Lens epithelium-derived growth factor (LEDGF)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      102892929..102925191 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287634.1XP_063143704.1  PC4 and SFRS1-interacting protein isoform X2

      UniProtKB/TrEMBL
      A0A8I5Y7G7, F1SW39
    2. XM_006238353.5XP_006238415.1  PC4 and SFRS1-interacting protein isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y7G7, F7FJ14
      Related
      ENSRNOP00000016130.2, ENSRNOT00000016130.5
      Conserved Domains (2) summary
      cd05834
      Location:387
      HDGF_related; The PWWP domain is an essential part of the Hepatoma Derived Growth Factor (HDGF) family of proteins, and is necessary for DNA binding by HDGF. This family of endogenous nuclear-targeted mitogens includes HRP (HDGF-related proteins 1, 2, 3, 4, or HPR1, ...
      pfam11467
      Location:348449
      LEDGF; Lens epithelium-derived growth factor (LEDGF)
    3. XM_017593365.3XP_017448854.1  PC4 and SFRS1-interacting protein isoform X4

      Conserved Domains (2) summary
      cd05834
      Location:387
      HDGF_related; The PWWP domain is an essential part of the Hepatoma Derived Growth Factor (HDGF) family of proteins, and is necessary for DNA binding by HDGF. This family of endogenous nuclear-targeted mitogens includes HRP (HDGF-related proteins 1, 2, 3, 4, or HPR1, ...
      cl30717
      Location:95245
      InfB; Translation initiation factor IF-2, a GTPase [Translation, ribosomal structure and biogenesis]
    4. XM_008763779.4XP_008762001.1  PC4 and SFRS1-interacting protein isoform X6

      See identical proteins and their annotated locations for XP_008762001.1

      UniProtKB/TrEMBL
      Q566D6
      Conserved Domains (2) summary
      cd05834
      Location:387
      HDGF_related; The PWWP domain is an essential part of the Hepatoma Derived Growth Factor (HDGF) family of proteins, and is necessary for DNA binding by HDGF. This family of endogenous nuclear-targeted mitogens includes HRP (HDGF-related proteins 1, 2, 3, 4, or HPR1, ...
      cl30717
      Location:95245
      InfB; Translation initiation factor IF-2, a GTPase [Translation, ribosomal structure and biogenesis]
    5. XM_017593366.3XP_017448855.1  PC4 and SFRS1-interacting protein isoform X8

      UniProtKB/TrEMBL
      A0A8I6AK62
      Related
      ENSRNOP00000068629.3, ENSRNOT00000082239.3
      Conserved Domains (2) summary
      cd05834
      Location:387
      HDGF_related; The PWWP domain is an essential part of the Hepatoma Derived Growth Factor (HDGF) family of proteins, and is necessary for DNA binding by HDGF. This family of endogenous nuclear-targeted mitogens includes HRP (HDGF-related proteins 1, 2, 3, 4, or HPR1, ...
      cl30717
      Location:95245
      InfB; Translation initiation factor IF-2, a GTPase [Translation, ribosomal structure and biogenesis]
    6. XM_039109886.2XP_038965814.1  PC4 and SFRS1-interacting protein isoform X3

      Conserved Domains (2) summary
      cd05834
      Location:387
      HDGF_related; The PWWP domain is an essential part of the Hepatoma Derived Growth Factor (HDGF) family of proteins, and is necessary for DNA binding by HDGF. This family of endogenous nuclear-targeted mitogens includes HRP (HDGF-related proteins 1, 2, 3, 4, or HPR1, ...
      cl30717
      Location:95245
      InfB; Translation initiation factor IF-2, a GTPase [Translation, ribosomal structure and biogenesis]
    7. XM_039109887.2XP_038965815.1  PC4 and SFRS1-interacting protein isoform X5

      UniProtKB/TrEMBL
      A0A0G2JTA2
      Conserved Domains (2) summary
      cd05834
      Location:387
      HDGF_related; The PWWP domain is an essential part of the Hepatoma Derived Growth Factor (HDGF) family of proteins, and is necessary for DNA binding by HDGF. This family of endogenous nuclear-targeted mitogens includes HRP (HDGF-related proteins 1, 2, 3, 4, or HPR1, ...
      cl30717
      Location:95245
      InfB; Translation initiation factor IF-2, a GTPase [Translation, ribosomal structure and biogenesis]
    8. XM_039109888.2XP_038965816.1  PC4 and SFRS1-interacting protein isoform X7

      Conserved Domains (2) summary
      cd05834
      Location:387
      HDGF_related; The PWWP domain is an essential part of the Hepatoma Derived Growth Factor (HDGF) family of proteins, and is necessary for DNA binding by HDGF. This family of endogenous nuclear-targeted mitogens includes HRP (HDGF-related proteins 1, 2, 3, 4, or HPR1, ...
      cl30717
      Location:95245
      InfB; Translation initiation factor IF-2, a GTPase [Translation, ribosomal structure and biogenesis]
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