Ppp1r3a protein phosphatase 1, regulatory subunit 3A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ppp1r3aprovided by RGD
Official Full Name: protein phosphatase 1, regulatory subunit 3Aprovided by RGD
Primary source: RGD:1561312
See related: EnsemblRapid:ENSRNOG00000059350 AllianceGenome:RGD:1561312
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1561312
Summary: Predicted to enable glycogen binding activity and protein phosphatase 1 binding activity. Predicted to be involved in regulation of glycogen biosynthetic process. Predicted to be located in membrane. Predicted to be part of protein phosphatase type 1 complex. Human ortholog(s) of this gene implicated in hypoglycemia and type 2 diabetes mellitus. Orthologous to human PPP1R3A (protein phosphatase 1 regulatory subunit 3A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 1639.9) See more
Orthologs: human mouse all
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Genomic context

Location:: 4q22

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (43905648..43946236, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (42937353..42980195, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (41171486..41212116, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RNA sequencing after Ppp1r3a knockdown in primary cultured neonatal rat ventricular myocytes validates network-based predictions and establish Ppp1r3a as a central regulator in heart failure.
Title: Pathologic gene network rewiring implicates PPP1R3A as a central regulator in pressure overload heart failure.
Rg1 through modulation of GDH and MFN2 maintained mitochondrial dynamics that resulted in protection against H/R-induced cardiomyocyte injury. All these results put forward a new protective mechanism of Rg1 on the therapeutic potential in cardiac I/R disorders.
Title: Rg1 prevents myocardial hypoxia/reoxygenation injury by regulating mitochondrial dynamics imbalance via modulation of glutamate dehydrogenase and mitofusin 2.

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General gene information

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Markers

AW533988 (e-PCR)
- UniSTS:246038

AI170678 (e-PCR)
- UniSTS:250492

RH139844 (e-PCR)
- UniSTS:221928

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables glycogen binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein phosphatase 1 binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in regulation of glycogen biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of protein phosphatase type 1 complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein phosphatase 1 regulatory subunit 3A

Names: protein phosphatase 1, regulatory (inhibitor) subunit 3A

NP_001102692.1

EC 3.1.3.16

XP_008760939.1

EC 3.1.3.16

XP_063142545.1

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109222.1 → NP_001102692.1 protein phosphatase 1 regulatory subunit 3A

See identical proteins and their annotated locations for NP_001102692.1

Status: PROVISIONAL

Source sequence(s)

CH473959

UniProtKB/TrEMBL

A6IE09

Related

ENSRNOP00000071537.3, ENSRNOT00000085596.3

Conserved Domains (1) summary

pfam03370
Location:124 → 231

CBM_21; Carbohydrate/starch-binding module (family 21)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

43905648..43946236 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008762717.4 → XP_008760939.1 protein phosphatase 1 regulatory subunit 3A isoform X1

UniProtKB/TrEMBL

D3ZM60

Conserved Domains (1) summary

pfam03370
Location:124 → 231

CBM_21; Carbohydrate/starch-binding module (family 21)
XM_063286475.1 → XP_063142545.1 protein phosphatase 1 regulatory subunit 3A isoform X2