Kcnk18 potassium two pore domain channel subfamily K member 18 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kcnk18provided by RGD
Official Full Name: potassium two pore domain channel subfamily K member 18provided by RGD
Primary source: RGD:1303091
See related: EnsemblRapid:ENSRNOG00000032706 AllianceGenome:RGD:1303091
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tresk-2
Summary: Predicted to enable calcium-activated potassium channel activity; outward rectifier potassium channel activity; and potassium ion leak channel activity. Predicted to be involved in cellular response to pH; potassium ion export across plasma membrane; and regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in migraine. Orthologous to human KCNK18 (potassium two pore domain channel subfamily K member 18). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 2.6) and Adrenal (RPKM 0.2) See more
Orthologs: human mouse all
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Genomic context

Location:: 1q55

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (268360738..268375012)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (258374671..258388945)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (280383579..280397784)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Upregulation of TRESK Channels Contributes to Motor and Sensory Recovery after Spinal Cord Injury.
Title: Upregulation of TRESK Channels Contributes to Motor and Sensory Recovery after Spinal Cord Injury.
reduction of functional TRESK channels in DRG neurons contributes to the sensitization of nociceptive sensory neurons and cancer pain development through enhancing neuronal excitability
Title: Decreased abundance of TRESK two-pore domain potassium channels in sensory neurons underlies the pain associated with bone metastasis.
The endogenous TRESK currents control the onset and the frequency of action potential in small-diameter TG neurons and the frameshift mutation results in hyperexcitability of these neurons.
Title: Functional analysis of a migraine-associated TRESK K+ channel mutation.
These results provide an anatomic basis for identifying functional roles of TRESK in the rat nervous system.
Title: Regional expression of the anesthetic-activated potassium channel TRESK in the rat nervous system.
TRESK-2 is a functional member of the K(2P) channel family and contributes to the background K+ conductance in many types of cells.
Title: Functional expression of TRESK-2, a new member of the tandem-pore K+ channel family.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium-activated potassium channel activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables outward rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables outward rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info
enables potassium channel activity	IEA Inferred from Electronic Annotation more info
enables potassium ion leak channel activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cellular response to pH	ISO Inferred from Sequence Orthology more info
involved_in potassium ion export across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within potassium ion transport	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transport	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in endomembrane system	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: potassium channel subfamily K member 18

Names: potassium channel, subfamily K, member 18; potassium channel, two pore domain subfamily K, member 18; tandem-pore K+ (K(2P)) channel; two-pore-domain potassium channel TRESK

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.