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    Wdr72 WD repeat domain 72 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300834, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Wdr72provided by RGD
    Official Full Name
    WD repeat domain 72provided by RGD
    Primary source
    RGD:1563550
    See related
    EnsemblRapid:ENSRNOG00000054889 AllianceGenome:RGD:1563550
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1563550
    Summary
    Predicted to be involved in protein localization to plasma membrane. Predicted to act upstream of or within several processes, including ameloblast differentiation; enamel mineralization; and protein-containing complex assembly. Predicted to be located in endosome and nucleus. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in amelogenesis imperfecta hypomaturation type 2A3. Orthologous to human WDR72 (WD repeat domain 72). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 172.3) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Wdr72 in Genome Data Viewer
    Location:
    8q24
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (83718897..83902128)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (74838338..75020938)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (80965734..81125710)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102554551 Neighboring gene unc-13 homolog C Neighboring gene 60S ribosomal protein L27-like Neighboring gene uncharacterized LOC120094209 Neighboring gene nucleophosmin 1, pseudogene 4 Neighboring gene uncharacterized LOC108351747

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Novel WDR72 mutation and cytoplasmic localization. Lee SK, et al. J Dent Res, 2010 Dec. PMID 20938048, Free PMC Article
    2. Critical roles for WDR72 in calcium transport and matrix protein removal during enamel maturation. Wang SK, et al. Mol Genet Genomic Med, 2015 Jul. PMID 26247047, Free PMC Article
    3. WDR72 models of structure and function: a stage-specific regulator of enamel mineralization. Katsura KA, et al. Matrix Biol, 2014 Sep. PMID 25008349, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within ameloblast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within amelogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within enamel mineralization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within extracellular matrix disassembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within extracellular matrix organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within microtubule polymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein import ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of pH ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within ruffle organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within tubulin complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within vesicle organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    WD repeat-containing protein 72

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135719.1 → NP_001129191.1  WD repeat-containing protein 72

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I6GHQ1
      Related
      ENSRNOP00000089019.1, ENSRNOT00000103226.2
      Conserved Domains (3) summary
      COG2319
      Location:338 → 597
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:20 → 60
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:408 → 596
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      83718897..83902128
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039081139.2 → XP_038937067.1  WD repeat-containing protein 72 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GHQ1
      Conserved Domains (2) summary
      sd00039
      Location:20 → 60
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:406 → 594
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. XM_063265177.1 → XP_063121247.1  WD repeat-containing protein 72 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K3H7, A0A8I5ZME2
      Related
      ENSRNOP00000072642.2, ENSRNOT00000079508.3
    Nucleotide Protein Strain
    Heading Accession and Version

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