Kcne4 potassium voltage-gated channel subfamily E regulatory subunit 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Kcne4provided by RGD
Full Name: potassium voltage-gated channel subfamily E regulatory subunit 4provided by RGD
Primary source: RGD:1302957
See related: EnsemblRapid:ENSRNOG00000071002 AllianceGenome:RGD:1302957
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable potassium channel inhibitor activity and transmembrane transporter binding activity. Predicted to contribute to delayed rectifier potassium channel activity and voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization. Predicted to be involved in several processes, including negative regulation of delayed rectifier potassium channel activity; potassium ion export across plasma membrane; and regulation of heart rate by cardiac conduction. Located in apical plasma membrane. Orthologous to human KCNE4 (potassium voltage-gated channel subfamily E regulatory subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 11.2), Uterus (RPKM 10.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q34

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (87674264..87699088)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (80243429..80251533)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (84688873..84693066)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

experimental data and the in silico structure suggest that the KCNE4 interaction hides a forward-trafficking motif within Kv1.3 in addition to adding a strong endoplasmic reticulum retention signature to the Kv1.3-KCNE4 complex.
Title: The calmodulin-binding tetraleucine motif of KCNE4 is responsible for association with Kv1.3.
Knockdown of KCNE4 leads to reduced Kv7.4 membrane abundance, a depolarized membrane potential and an augmented response to vasoconstrictors.
Title: Fundamental role for the KCNE4 ancillary subunit in Kv7.4 regulation of arterial tone.
MiRP3 (encoded by the KCNE4 gene) plays a role in modulation of BK-dependent urinary potassium excretion.
Title: MiRP3 acts as an accessory subunit with the BK potassium channel.
Apparent association with BK channel in renal collecting duct
Title: MiRP3 acts as an accessory subunit with the BK potassium channel.
Mouse studies regarding function of mouse Kcne4 protein
Title: KCNE4 is an inhibitory subunit to Kv1.1 and Kv1.3 potassium channels.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
contributes_to delayed rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium channel inhibitor activity	ISO Inferred from Sequence Orthology more info
enables potassium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter binding	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info
contributes_to voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in membrane repolarization during action potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in membrane repolarization during ventricular cardiac muscle cell action potential	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of delayed rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion export across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of heart rate by cardiac conduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of ventricular cardiac muscle cell membrane repolarization	IBA Inferred from Biological aspect of Ancestor more info
involved_in ventricular cardiac muscle cell action potential	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: potassium voltage-gated channel subfamily E member 4

Names: minK-related peptide 3; potassium channel, voltage gated subfamily E regulatory beta subunit 4; potassium channel, voltage-gated Isk-related subfamily E regulatory beta subunit 4; potassium voltage-gated channel, Isk-related family, member 4; potassium voltage-gated channel, Isk-related subfamily, gene 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212526.1 → NP_997691.1 potassium voltage-gated channel subfamily E member 4

See identical proteins and their annotated locations for NP_997691.1

Status: PROVISIONAL

Source sequence(s)

AF512994

UniProtKB/TrEMBL

A0A8I5ZKN5, Q71FD8

Related

ENSRNOP00000103778.1, ENSRNOT00000165428.1

Conserved Domains (1) summary

pfam02060
Location:9 → 64

ISK_Channel; Slow voltage-gated potassium channel

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

87674264..87699088

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039083975.2 → XP_038939903.1 potassium voltage-gated channel subfamily E member 4 isoform X1

UniProtKB/TrEMBL

A0A8I5ZKN5, Q71FD8

Related

ENSRNOP00000107227.1, ENSRNOT00000163801.1

Conserved Domains (1) summary

pfam02060
Location:9 → 64

ISK_Channel; Slow voltage-gated potassium channel