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    Krt84 keratin 84 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315320, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Krt84provided by RGD
    Official Full Name
    keratin 84provided by RGD
    Primary source
    RGD:1359402
    See related
    EnsemblRapid:ENSRNOG00000008819 AllianceGenome:RGD:1359402
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Kb24
    Summary
    Predicted to be a structural constituent of skin epidermis. Predicted to be involved in intermediate filament organization; keratinization; and regulation of keratinocyte differentiation. Predicted to be located in intermediate filament cytoskeleton. Predicted to be active in keratin filament. Orthologous to human KRT84 (keratin 84). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 1.8), Muscle (RPKM 1.2) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Krt84 in Genome Data Viewer
    Location:
    7q36
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (134527787..134535608, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (132649064..132656885, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (143180212..143187684, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene keratin 83 Neighboring gene keratin 85 Neighboring gene keratin 82 Neighboring gene keratin 90

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structural features and sites of expression of a new murine 65 kD and 48 kD hair-related keratin pair, associated with a special type of parakeratotic epithelial differentiation. Tobiasch E, et al. Differentiation, 1992 Aug. PMID 1385239
    2. Characterization of a 300 kbp region of human DNA containing the type II hair keratin gene domain. Rogers MA, et al. J Invest Dermatol, 2000 Mar. PMID 10692104
    3. Comprehensive analysis of keratin gene clusters in humans and rodents. Hesse M, et al. Eur J Cell Biol, 2004 Feb. PMID 15085952
    4. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables structural constituent of skin epidermis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of skin epidermis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in intermediate filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in keratinization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of keratinocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in intermediate filament cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in keratin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in keratin filament ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    keratin, type II cuticular Hb4
    Names
    keratin 84, type II
    type II keratin Kb24

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008812.2 → NP_001008812.2  keratin, type II cuticular Hb4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A0G2K0I4, A6KCQ4, D3ZSY5, Q6IG07
      Related
      ENSRNOP00000071459.1, ENSRNOT00000083466.3
      Conserved Domains (2) summary
      pfam00038
      Location:177 → 487
      Filament; Intermediate filament protein
      pfam16208
      Location:16 → 173
      Keratin_2_head; Keratin type II head

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      134527787..134535608 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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