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    Myo3b myosin IIIB [ Rattus norvegicus (Norway rat) ]

    Gene ID: 366069, updated on 4-Jan-2025

    Summary

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    Symbol
    Myo3bprovided by RGD
    Full Name
    myosin IIIBprovided by RGD
    Primary source
    RGD:1560313
    See related
    EnsemblRapid:ENSRNOG00000030022 AllianceGenome:RGD:1560313
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1560313
    Summary
    Predicted to enable microfilament motor activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including inner ear morphogenesis; positive regulation of filopodium assembly; and sensory perception of sound. Predicted to act upstream of or within peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; and protein autophosphorylation. Predicted to be located in photoreceptor outer segment. Predicted to be part of myosin complex. Predicted to be active in filopodium tip; photoreceptor inner segment; and stereocilium tip. Orthologous to human MYO3B (myosin IIIB). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Kidney (RPKM 32.8), Lung (RPKM 11.4) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Myo3b in Genome Data Viewer
    Location:
    3q22
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (75228017..75636272)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (54820225..55228518)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (56355433..56717740)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene methyltransferase 5, N6-adenosine Neighboring gene small RNA binding exonuclease protection factor La Neighboring gene ubiquitin protein ligase E3 component n-recognin 3 Neighboring gene heterogeneous nuclear ribonucleoprotein C, pseudogene 5 Neighboring gene uncharacterized LOC134486377 Neighboring gene uncharacterized LOC134486378 Neighboring gene uncharacterized LOC134486379 Neighboring gene uncharacterized LOC120101561 Neighboring gene Sp5 transcription factor Neighboring gene glutamate-rich 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mouse class III myosins: kinase activity and phosphorylation sites. Dalal JS, et al. J Neurochem, 2011 Nov. PMID 21895655, Free PMC Article
    2. Myosin IIIB uses an actin-binding motif in its espin-1 cargo to reach the tips of actin protrusions. Merritt RC, et al. Curr Biol, 2012 Feb 21. PMID 22264607, Free PMC Article
    3. Cloning and distribution of myosin 3B in the mouse retina: differential distribution in cone outer segments. Katti C, et al. Exp Eye Res, 2009 Aug. PMID 19332056, Free PMC Article
    4. Class III myosins shape the auditory hair bundles by limiting microvilli and stereocilia growth. Lelli A, et al. J Cell Biol, 2016 Jan 18. PMID 26754646, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microfilament motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microfilament motor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in auditory receptor cell stereocilium organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cochlea morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of filopodium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of filopodium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of actin filament length IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of actin filament length ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sensory perception of sound IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sensory perception of sound ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in visual perception IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in filopodium tip IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in filopodium tip ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in photoreceptor inner segment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in photoreceptor inner segment ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in photoreceptor outer segment ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in stereocilium tip IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in stereocilium tip ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in stereocilium tip ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    myosin-IIIb
    NP_001380706.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001393777.1 → NP_001380706.1  myosin-IIIb

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      F1LWJ6
      Related
      ENSRNOP00000032998.7, ENSRNOT00000037188.8
      Conserved Domains (3) summary
      smart00015
      Location:1102 → 1124
      IQ; Calmodulin-binding motif
      cd01379
      Location:373 → 1062
      MYSc_Myo3; class III myosin, motor domain
      cl21453
      Location:20 → 310
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      75228017..75636272
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001191901.1: Suppressed sequence

      Description
      NM_001191901.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
    Nucleotide Protein Strain
    Heading Accession and Version

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