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    Boll boule homolog, RNA binding protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 501143, updated on 4-Jan-2025

    Summary

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    Symbol
    Bollprovided by RGD
    Full Name
    boule homolog, RNA binding proteinprovided by RGD
    Primary source
    RGD:1559527
    See related
    EnsemblRapid:ENSRNOG00000054379 AllianceGenome:RGD:1559527
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1559527
    Summary
    Predicted to enable identical protein binding activity; mRNA 3'-UTR binding activity; and translation activator activity. Predicted to be involved in 3'-UTR-mediated mRNA stabilization and positive regulation of translational initiation. Predicted to act upstream of or within meiotic cell cycle. Predicted to be active in cytoplasm. Orthologous to human BOLL (boule homolog, RNA binding protein). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Testes (RPKM 72.4) and Adrenal (RPKM 2.9) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Boll in Genome Data Viewer
    Location:
    9q31
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (64225411..64354394, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (56734890..56859917, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (61836517..61975640, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene glycine cleavage system H protein, mitochondrial pseudogene Neighboring gene MOB family member 4, phocein Neighboring gene raftlin family member 2 Neighboring gene methionyl-tRNA synthetase 2, mitochondrial Neighboring gene uncharacterized LOC120094794 Neighboring gene uncharacterized LOC134480577 Neighboring gene phospholipase C-like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The DAZL family proteins are PABP-binding proteins that regulate translation in germ cells. Collier B, et al. EMBO J, 2005 Jul 20. PMID 16001084, Free PMC Article
    2. A gene family required for human germ cell development evolved from an ancient meiotic gene conserved in metazoans. Xu EY, et al. Proc Natl Acad Sci U S A, 2001 Jun 19. PMID 11390979, Free PMC Article
    3. Human BOULE gene rescues meiotic defects in infertile flies. Xu EY, et al. Hum Mol Genet, 2003 Jan 15. PMID 12499397
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in 3'-UTR-mediated mRNA stabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within meiotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein boule-like
    Names
    bol, boule-like
    boule-like RNA-binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113370.2 → NP_001106841.1  protein boule-like isoform 4

      See identical proteins and their annotated locations for NP_001106841.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A6IP19
      Conserved Domains (2) summary
      COG0724
      Location:44 → 125
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12673
      Location:43 → 123
      RRM_BOULE; RNA recognition motif in protein BOULE

    2. NM_001432509.1 → NP_001419438.1  protein boule-like isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009

    3. NM_001432510.1 → NP_001419439.1  protein boule-like isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009

    4. NM_001432517.1 → NP_001419446.1  protein boule-like isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A0G2JYK5

    5. NM_001432518.1 → NP_001419447.1  protein boule-like isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009

    6. NM_001432519.1 → NP_001419448.1  protein boule-like isoform 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009

    7. NM_001432520.1 → NP_001419449.1  protein boule-like isoform 7

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009

    8. NM_001432521.1 → NP_001419450.1  protein boule-like isoform 8

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009

    9. NM_001432522.1 → NP_001419451.1  protein boule-like isoform 9

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A6IP20

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      64225411..64354394 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006244941.5 → XP_006245003.1  protein boule-like isoform X1

      Conserved Domains (2) summary
      TIGR01628
      Location:45 → 293
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12673
      Location:43 → 123
      RRM_BOULE; RNA recognition motif (RRM) found in protein BOULE

    2. XM_039084083.2 → XP_038940011.1  protein boule-like isoform X2

      Conserved Domains (1) summary
      cd12673
      Location:43 → 123
      RRM_BOULE; RNA recognition motif (RRM) found in protein BOULE

    3. XM_039084084.2 → XP_038940012.1  protein boule-like isoform X4

      Conserved Domains (2) summary
      TIGR01628
      Location:45 → 271
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12673
      Location:43 → 123
      RRM_BOULE; RNA recognition motif (RRM) found in protein BOULE

    4. XM_039084086.2 → XP_038940014.1  protein boule-like isoform X8

    5. XM_039084085.2 → XP_038940013.1  protein boule-like isoform X5

      Related
      ENSRNOP00000070691.2, ENSRNOT00000085744.3
      Conserved Domains (2) summary
      TIGR01628
      Location:45 → 283
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12673
      Location:43 → 123
      RRM_BOULE; RNA recognition motif (RRM) found in protein BOULE

    6. XM_063267600.1 → XP_063123670.1  protein boule-like isoform X3

    7. XM_063267603.1 → XP_063123673.1  protein boule-like isoform X10

      UniProtKB/TrEMBL
      A6IP20

    8. XM_017596602.3 → XP_017452091.1  protein boule-like isoform X6

      Conserved Domains (2) summary
      COG0724
      Location:44 → 125
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12673
      Location:43 → 123
      RRM_BOULE; RNA recognition motif in protein BOULE

    9. XM_063267602.1 → XP_063123672.1  protein boule-like isoform X7

    10. XM_039084087.2 → XP_038940015.1  protein boule-like isoform X9

      Conserved Domains (1) summary
      cd12673
      Location:43 → 123
      RRM_BOULE; RNA recognition motif (RRM) found in protein BOULE

    RNA

    1. XR_001839681.3 RNA Sequence

      Related
      ENSRNOT00000148143.1

    2. XR_005488953.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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