Npbwr1 neuropeptides B and W receptor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Npbwr1provided by RGD
Official Full Name: neuropeptides B and W receptor 1provided by RGD
Primary source: RGD:1305917
See related: EnsemblRapid:ENSRNOG00000071533 AllianceGenome:RGD:1305917
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gpr7; Nbpwr1
Summary: Predicted to enable G protein-coupled receptor activity and neuropeptide binding activity. Predicted to be involved in neuropeptide signaling pathway. Predicted to act upstream of or within regulation of metabolic process. Predicted to be active in neuron projection and plasma membrane. Orthologous to human NPBWR1 (neuropeptides B and W receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: 5q12

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (18282180..18285622)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (13495319..13498761)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (13379772..13380761)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identification of NPB, NPW and Their Receptor in the Rat Heart.
Title: Identification of NPB, NPW and Their Receptor in the Rat Heart.
demonstrates the expression patterns of GPR7, NPB, and NPW precursor messenger ribonucleic acid (mRNA) in the rat brain by using in situ hybridization and in situ binding experiments
Title: A study of the rat neuropeptide B/neuropeptide W system using in situ techniques.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide binding	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: neuropeptides B/W receptor type 1

Names: G-protein coupled receptor 7; neuropeptides B/W receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001014784.2 → NP_001014784.1 neuropeptides B/W receptor type 1

See identical proteins and their annotated locations for NP_001014784.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

Q56UD9

Related

ENSRNOP00000109924.1, ENSRNOT00000125178.1

Conserved Domains (1) summary

cd15087
Location:40 → 320

7tmA_NPBWR; neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors