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    Ilrun inflammation and lipid regulator with UBA-like and NBR1-like domains [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294154, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ilrunprovided by RGD
    Official Full Name
    inflammation and lipid regulator with UBA-like and NBR1-like domainsprovided by RGD
    Primary source
    RGD:1559829
    See related
    EnsemblRapid:ENSRNOG00000038883 AllianceGenome:RGD:1559829
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310148
    Summary
    Predicted to enable ubiquitin binding activity. Predicted to be involved in several processes, including negative regulation of cytokine production; negative regulation of defense response to virus; and negative regulation of protein localization to nucleus. Predicted to be located in centrosome; cytosol; and nuclear speck. Predicted to be active in phagophore assembly site. Orthologous to human ILRUN (inflammation and lipid regulator with UBA-like and NBR1-like domains). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 809.1), Kidney (RPKM 486.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ilrun in Genome Data Viewer
    Location:
    20p12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (5811721..5878082, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (5809931..5876197, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (7331321..7397588, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene protein kinase C and casein kinase substrate in neurons 1 Neighboring gene SAM pointed domain containing ets transcription factor Neighboring gene uncharacterized LOC134483861 Neighboring gene small nuclear ribonucleoprotein polypeptide C Neighboring gene small nucleolar RNA SNORA26 Neighboring gene bridge-like lipid transfer protein family member 3A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. C6orf106 is a novel inhibitor of the interferon-regulatory factor 3-dependent innate antiviral response. Ambrose RL, et al. J Biol Chem, 2018 Jul 6. PMID 29802199, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC124820

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in macroautophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of defense response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of type I interferon production ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in phagophore assembly site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein ILRUN
    Names
    chromosome 6 open reading frame 106-like
    uncharacterized protein C6orf106 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039607.2 → NP_001034696.1  protein ILRUN isoform 2

      See identical proteins and their annotated locations for NP_001034696.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      A0A8I5ZQ01, F1MAI9, Q2M1K7
      Related
      ENSRNOP00000093528.1, ENSRNOT00000111162.2
      Conserved Domains (2) summary
      cd14349
      Location:23 → 64
      UBA_CF106; UBA-like domain found in uncharacterized protein C6orf106 and similar proteins
      cd14947
      Location:71 → 180
      NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins

    2. NM_001410292.1 → NP_001397221.1  protein ILRUN isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      A0A8J8XEJ8, A6JJN5
      Related
      ENSRNOP00000056183.4, ENSRNOT00000059426.6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      5811721..5878082 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063278990.1 → XP_063135060.1  protein ILRUN isoform X1

      UniProtKB/TrEMBL
      A6JJN5
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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