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    Nkiras2 NFKB inhibitor interacting Ras-like 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287707, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nkiras2provided by RGD
    Official Full Name
    NFKB inhibitor interacting Ras-like 2provided by RGD
    Primary source
    RGD:1307363
    See related
    EnsemblRapid:ENSRNOG00000018095 AllianceGenome:RGD:1307363
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GTPase activating protein binding activity. Predicted to be involved in Ral protein signal transduction. Predicted to act upstream of or within several processes, including lung alveolus development; regulation of signal transduction; and surfactant homeostasis. Predicted to be located in cytoplasm. Orthologous to human NKIRAS2 (NFKB inhibitor interacting Ras like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 123.8), Muscle (RPKM 109.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nkiras2 in Genome Data Viewer
    Location:
    10q31
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (86055029..86062398)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (85554704..85562072)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (88536564..88540739)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene outer dynein arm docking complex subunit 4 Neighboring gene 2',3'-cyclic nucleotide 3' phosphodiesterase Neighboring gene DnaJ heat shock protein family (Hsp40) member C7 Neighboring gene small nucleolar RNA SNORA44 Neighboring gene chromosome 10 C17orf113 homolog pseudogene Neighboring gene zinc finger protein 385C Neighboring gene uncharacterized LOC120095293

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activating protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activating protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Ral protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within Ral protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lung alveolus development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of tumor necrosis factor-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within surfactant homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    NF-kappa-B inhibitor-interacting Ras-like protein 2
    Names
    NFKB inhibitor interacting Ras-like protein 2
    NP_001099309.1
    XP_006247336.1
    XP_038941539.1
    XP_063124805.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105839.1 → NP_001099309.1  NF-kappa-B inhibitor-interacting Ras-like protein 2

      See identical proteins and their annotated locations for NP_001099309.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473948
      UniProtKB/TrEMBL
      A6HJ49, D3ZCK2
      Related
      ENSRNOP00000024543.4, ENSRNOT00000024543.7
      Conserved Domains (1) summary
      cl38936
      Location:6 → 168
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      86055029..86062398
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085611.2 → XP_038941539.1  NF-kappa-B inhibitor-interacting Ras-like protein 2 isoform X1

      UniProtKB/TrEMBL
      A6HJ49, D3ZCK2
      Conserved Domains (1) summary
      cl38936
      Location:6 → 168
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. XM_063268735.1 → XP_063124805.1  NF-kappa-B inhibitor-interacting Ras-like protein 2 isoform X1

      UniProtKB/TrEMBL
      A6HJ49, D3ZCK2

    3. XM_006247274.5 → XP_006247336.1  NF-kappa-B inhibitor-interacting Ras-like protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006247336.1

      UniProtKB/TrEMBL
      A6HJ49, D3ZCK2
      Conserved Domains (1) summary
      cl38936
      Location:6 → 168
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version

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