Tle1 TLE family member 1, transcriptional corepressor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tle1provided by RGD
Official Full Name: TLE family member 1, transcriptional corepressorprovided by RGD
Primary source: RGD:1309237
See related: EnsemblRapid:ENSRNOG00000005882 AllianceGenome:RGD:1309237
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including chromatin binding activity; identical protein binding activity; and transcription corepressor activity. Predicted to be involved in negative regulation of anoikis; negative regulation of signal transduction; and regulation of gene expression. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of beta-catenin-TCF complex. Predicted to be active in nucleus. Orthologous to human TLE1 (TLE family member 1, transcriptional corepressor). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 70.6), Lung (RPKM 58.7) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5q31

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (90898182..90982118, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (85851827..85934806, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (88546607..88630277, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GRg1 inhibits the TLR4/NF-kB signaling pathway by upregulating miR-216a-5p to reduce growth factors and inflammatory cytokines in DR.
Title: GRg1 inhibits the TLR4/NF-kB signaling pathway by upregulating miR-216a-5p to reduce growth factors and inflammatory cytokines in DR.
TLE1 cooperates with FoxG1 to promote neuronal survival in a CK2- and PI3K-Akt-dependent manner.
Title: Transducin-like enhancer of Split-1 (TLE1) combines with Forkhead box protein G1 (FoxG1) to promote neuronal survival.
TLE1 expression was mostly localized to neurons and occurs in mature cortical and cerebellar neurons.
Title: Dendritic localization of the transcriptional co-repressor Groucho/TLE1 in cortical and cerebellar neurons.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH141090 (e-PCR)
- UniSTS:223088

D5Rat85 (e-PCR)
- UniSTS:118933

WI-12646 (e-PCR)
- UniSTS:951

D5Got125 (e-PCR)
- UniSTS:114889

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of anoikis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of beta-catenin-TCF complex	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription regulator complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transducin-like enhancer protein 1

Names: transducin like enhancer of split 1; transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001173433.1 → NP_001166904.1 transducin-like enhancer protein 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

D3ZCM7

Related

ENSRNOP00000055692.4, ENSRNOT00000058906.5

Conserved Domains (3) summary

cd00200
Location:483 → 767

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:487 → 526

7WD40; WD40 repeat [structural motif]

pfam03920
Location:9 → 133

TLE_N; Groucho/TLE N-terminal Q-rich domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

90898182..90982118 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017593478.3 → XP_017448967.1 transducin-like enhancer protein 1 isoform X12

UniProtKB/TrEMBL

D3ZCM7

Related

ENSRNOP00000095904.2, ENSRNOT00000098507.2

Conserved Domains (4) summary

PHA03378
Location:231 → 393

PHA03378; EBNA-3B; Provisional

cd00200
Location:409 → 693

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:413 → 452

7WD40; WD40 repeat [structural motif]

pfam03920
Location:9 → 128

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_039110257.2 → XP_038966185.1 transducin-like enhancer protein 1 isoform X10

UniProtKB/TrEMBL

D3ZCM7
XM_006238293.5 → XP_006238355.1 transducin-like enhancer protein 1 isoform X13

UniProtKB/TrEMBL

D3ZCM7

Conserved Domains (3) summary

cd00200
Location:481 → 765

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:485 → 524

7WD40; WD40 repeat [structural motif]

pfam03920
Location:9 → 132

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_006238288.5 → XP_006238350.1 transducin-like enhancer protein 1 isoform X8

UniProtKB/TrEMBL

D3ZCM7

Conserved Domains (3) summary

cd00200
Location:482 → 766

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:486 → 525

7WD40; WD40 repeat [structural motif]

pfam03920
Location:9 → 132

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_006238284.5 → XP_006238346.1 transducin-like enhancer protein 1 isoform X4

UniProtKB/TrEMBL

D3ZCM7

Conserved Domains (3) summary

cd00200
Location:516 → 800

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:520 → 559

7WD40; WD40 repeat [structural motif]

pfam03920
Location:9 → 132

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_006238287.5 → XP_006238349.1 transducin-like enhancer protein 1 isoform X7

UniProtKB/TrEMBL

D3ZCM7

Conserved Domains (3) summary

cd00200
Location:482 → 766

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:486 → 525

7WD40; WD40 repeat [structural motif]

pfam03920
Location:9 → 133

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_006238283.5 → XP_006238345.1 transducin-like enhancer protein 1 isoform X3

UniProtKB/TrEMBL

A0A8I6AT29, D3ZCM7

Related

ENSRNOP00000097506.1, ENSRNOT00000102954.2

Conserved Domains (3) summary

cd00200
Location:517 → 801

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:521 → 560

7WD40; WD40 repeat [structural motif]

pfam03920
Location:9 → 133

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_008763786.4 → XP_008762008.2 transducin-like enhancer protein 1 isoform X2

UniProtKB/TrEMBL

D3ZCM7

Conserved Domains (3) summary

cd00200
Location:526 → 810

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:530 → 569

7WD40; WD40 repeat [structural motif]

pfam03920
Location:9 → 142

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_006238286.5 → XP_006238348.1 transducin-like enhancer protein 1 isoform X6

UniProtKB/TrEMBL

D3ZCM7

Conserved Domains (3) summary

cd00200
Location:492 → 776

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:496 → 535

7WD40; WD40 repeat [structural motif]

pfam03920
Location:9 → 143

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_017593476.3 → XP_017448965.1 transducin-like enhancer protein 1 isoform X5

UniProtKB/TrEMBL

A0A8I6A8I5, D3ZCM7

Related

ENSRNOP00000088662.1, ENSRNOT00000116062.2

Conserved Domains (3) summary

cd00200
Location:493 → 777

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:497 → 536

7WD40; WD40 repeat [structural motif]

pfam03920
Location:9 → 143

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_006238281.5 → XP_006238343.1 transducin-like enhancer protein 1 isoform X1

UniProtKB/TrEMBL

D3ZCM7

Conserved Domains (3) summary

cd00200
Location:527 → 811

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:531 → 570

7WD40; WD40 repeat [structural motif]

pfam03920
Location:9 → 143

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_006238289.4 → XP_006238351.1 transducin-like enhancer protein 1 isoform X9

UniProtKB/TrEMBL

A0A0G2K324

Related

ENSRNOP00000072474.1, ENSRNOT00000089560.3

Conserved Domains (4) summary

COG2319
Location:468 → 760

WD40; WD40 repeat [General function prediction only]

cd00200
Location:475 → 759

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam03920
Location:27 → 91

TLE_N; Groucho/TLE N-terminal Q-rich domain

sd00039
Location:479 → 518

7WD40; WD40 repeat [structural motif]
XM_008763792.3 → XP_008762014.1 transducin-like enhancer protein 1 isoform X11

See identical proteins and their annotated locations for XP_008762014.1

UniProtKB/TrEMBL

A0A0G2K324

Conserved Domains (3) summary

COG2319
Location:405 → 697

WD40; WD40 repeat [General function prediction only]

cd00200
Location:412 → 696

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:416 → 455

7WD40; WD40 repeat [structural motif]