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    Dmwd DM1 locus, WD repeat containing [ Rattus norvegicus (Norway rat) ]

    Gene ID: 680252, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dmwdprovided by RGD
    Official Full Name
    DM1 locus, WD repeat containingprovided by RGD
    Primary source
    RGD:1594179
    See related
    EnsemblRapid:ENSRNOG00000014984 AllianceGenome:RGD:1594179
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable deubiquitinase activator activity. Predicted to be located in cytoplasm and nucleus. Orthologous to human DMWD (DM1 locus, WD repeat containing). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 67.2), Brain (RPKM 66.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dmwd in Genome Data Viewer
    Location:
    1q21
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (87850475..87857263)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (78722436..78729224)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (79981270..79987997)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene transfer RNA glycine (anticodon ACC) 6 Neighboring gene radial spoke head 6 homolog A Neighboring gene jupiter microtubule associated homolog 1-like Neighboring gene uncharacterized LOC108349062 Neighboring gene DM1 protein kinase Neighboring gene SIX homeobox 5 Neighboring gene meiosis initiator

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables deubiquitinase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dystrophia myotonica WD repeat-containing protein
    Names
    dystrophia myotonica, WD repeat containing

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001401247.1 → NP_001388176.1  dystrophia myotonica WD repeat-containing protein

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      F1M3D2, M0RDT6
      Related
      ENSRNOP00000103603.1, ENSRNOT00000165590.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      87850475..87857263
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008759039.3 → XP_008757261.1  dystrophia myotonica WD repeat-containing protein isoform X1

      UniProtKB/TrEMBL
      F1M3D2
      Conserved Domains (3) summary
      COG2319
      Location:98 → 376
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:214 → 279
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:281 → 375
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. XM_017589996.2 → XP_017445485.1  dystrophia myotonica WD repeat-containing protein isoform X2

    3. XM_017589997.3 → XP_017445486.1  dystrophia myotonica WD repeat-containing protein isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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