Dpp6 dipeptidyl peptidase like 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dpp6provided by RGD
Official Full Name: dipeptidyl peptidase like 6provided by RGD
Primary source: RGD:68402
See related: EnsemblRapid:ENSRNOG00000030547 AllianceGenome:RGD:68402
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: DPP VI
Summary: Predicted to enable potassium channel regulator activity. Involved in positive regulation of potassium ion transport and positive regulation of protein localization to plasma membrane. Located in cell surface and neuronal cell body. Part of voltage-gated potassium channel complex. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; autosomal dominant intellectual developmental disorder 33; and spinal muscular atrophy. Orthologous to human DPP6 (dipeptidyl peptidase like 6). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 198.4) and Adrenal (RPKM 21.9) See more
Orthologs: human mouse all
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Genomic context

Location:: 4q11

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (8323220..9242694, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (7589386..8508666, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (4021021..4943675, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dipeptidyl-peptidase 6 has an unexpected but important role in cell adhesion and motility, impacting the hippocampal synaptic development and function.
Title: DPP6 regulation of dendritic morphogenesis impacts hippocampal synaptic development.
The unique N-terminus of DPP6K modulates the effects of KChIP proteins, slowing recovery and producing a negative shift in the steady-state inactivation curve.
Title: Incorporation of DPP6a and DPP6K variants in ternary Kv4 channel complex reconstitutes properties of A-type K current in rat cerebellar granule cells.
a novel component of A-type K(+) channels
Title: The CD26-related dipeptidyl aminopeptidase-like protein DPPX is a critical component of neuronal A-type K+ channels.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D5Jcs89 (e-PCR), detects polymorphism
- UniSTS:507911

AU028887 (e-PCR)
- UniSTS:111896

D4Rat139 (e-PCR)
- UniSTS:118815

d4arb13 (e-PCR)
- UniSTS:121904

D4Got1 (e-PCR)
- UniSTS:112002

d4rat4 (e-PCR)
- UniSTS:122011

D4Got2 (e-PCR)
- UniSTS:112317

D4Got5 (e-PCR)
- UniSTS:112591

D4Rat249 (e-PCR), detects polymorphism
- UniSTS:227792

Dpp6 (e-PCR), detects polymorphism
- UniSTS:548059

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
NOT enables dipeptidyl-peptidase activity	ISO Inferred from Sequence Orthology more info
NOT enables dipeptidyl-peptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables potassium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium channel regulator activity	IEA Inferred from Electronic Annotation more info
enables potassium channel regulator activity	ISO Inferred from Sequence Orthology more info
enables potassium channel regulator activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables serine-type peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of establishment of localization in cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuronal action potential	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of potassium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein localization to plasma membrane	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of membrane potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynaptic membrane potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of potassium ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of potassium ion transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	IDA Inferred from Direct Assay more info	PubMed
part_of voltage-gated potassium channel complex	IEA Inferred from Electronic Annotation more info
part_of voltage-gated potassium channel complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: A-type potassium channel modulatory protein DPP6; dipeptidyl aminopeptidase-like protein 6

Names: DPPX; dipeptidyl aminopeptidase-related protein; dipeptidyl peptidase IV-like protein; dipeptidyl peptidase VI; dipeptidylpeptidase 6; dipeptidylpeptidase VI

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022850.2 → NP_074041.2 A-type potassium channel modulatory protein DPP6

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000004

UniProtKB/Swiss-Prot

P46101

UniProtKB/TrEMBL

A0A8I6A0E2

Related

ENSRNOP00000084952.1, ENSRNOT00000108476.2

Conserved Domains (2) summary

pfam00930
Location:189 → 555

DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

cl21494
Location:635 → 844

Abhydrolase; alpha/beta hydrolases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

8323220..9242694 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017592501.3 → XP_017447990.1 dipeptidyl aminopeptidase-like protein 6 isoform X1

UniProtKB/TrEMBL

A0A8I5ZQR2, A6KJK3

Related

ENSRNOP00000080650.1, ENSRNOT00000117212.2

Conserved Domains (2) summary

pfam00930
Location:134 → 500

DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

cl21494
Location:580 → 789

Abhydrolase; alpha/beta hydrolases
XM_017592503.3 → XP_017447992.1 dipeptidyl aminopeptidase-like protein 6 isoform X3

UniProtKB/TrEMBL

A0A8I5ZR04, A6KJK3

Related

ENSRNOP00000080741.1, ENSRNOT00000093848.2

Conserved Domains (2) summary

pfam00930
Location:131 → 497

DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

cl21494
Location:577 → 786

Abhydrolase; alpha/beta hydrolases
XM_017592504.3 → XP_017447993.1 dipeptidyl aminopeptidase-like protein 6 isoform X4

UniProtKB/TrEMBL

A6KJK3
XM_006235880.5 → XP_006235942.1 dipeptidyl aminopeptidase-like protein 6 isoform X2

UniProtKB/TrEMBL

A6KJK3, F1LMR7

Related

ENSRNOP00000043113.2, ENSRNOT00000045773.4

Conserved Domains (2) summary

pfam00930
Location:133 → 499

DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

cl21494
Location:579 → 788

Abhydrolase; alpha/beta hydrolases
XM_063285681.1 → XP_063141751.1 dipeptidyl aminopeptidase-like protein 6 isoform X5
XM_063285682.1 → XP_063141752.1 dipeptidyl aminopeptidase-like protein 6 isoform X6