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    Actr5 actin related protein 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362258, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Actr5provided by RGD
    Official Full Name
    actin related protein 5provided by RGD
    Primary source
    RGD:1307958
    See related
    EnsemblRapid:ENSRNOG00000023989 AllianceGenome:RGD:1307958
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in several processes, including DNA metabolic process; regulation of embryonic development; and regulation of nucleobase-containing compound metabolic process. Predicted to be located in nucleus. Predicted to be part of Ino80 complex. Predicted to be active in cytoplasm. Orthologous to human ACTR5 (actin related protein 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 35.4), Spleen (RPKM 33.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Actr5 in Genome Data Viewer
    Location:
    3q42
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (167702299..167715736)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (147282461..147295870)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (155118567..155132073)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120101774 Neighboring gene solute carrier family 32 member 1 Neighboring gene protein phosphatase 1, regulatory subunit 16B Neighboring gene 60S ribosomal protein L13-like Neighboring gene family with sequence similarity 83, member D

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The human actin-related protein hArp5: nucleo-cytoplasmic shuttling and involvement in DNA repair. Kitayama K, et al. Exp Cell Res, 2009 Jan 15. PMID 19014934
    2. INO80 chromatin remodeling complex promotes the removal of UV lesions by the nucleotide excision repair pathway. Jiang Y, et al. Proc Natl Acad Sci U S A, 2010 Oct 5. PMID 20855601, Free PMC Article
    3. A YY1-INO80 complex regulates genomic stability through homologous recombination-based repair. Wu S, et al. Nat Struct Mol Biol, 2007 Dec. PMID 18026119, Free PMC Article
    4. Subunit organization of the human INO80 chromatin remodeling complex: an evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling. Chen L, et al. J Biol Chem, 2011 Apr 1. PMID 21303910, Free PMC Article
    5. The INO80 family of chromatin-remodeling enzymes: regulators of histone variant dynamics. Watanabe S, et al. Cold Spring Harb Symp Quant Biol, 2010. PMID 21502417

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in UV-damage excision repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in double-strand break repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of telomere maintenance in response to DNA damage ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA strand elongation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of chromosome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in telomere maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Ino80 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Ino80 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    actin-related protein 5
    Names
    ARP5 actin-related protein 5 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395604.1 → NP_001382533.1  actin-related protein 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      D3ZAQ1
      Related
      ENSRNOP00000036100.7, ENSRNOT00000032943.8
      Conserved Domains (2) summary
      pfam07564
      Location:344 → 385
      DUF1542; Domain of Unknown Function (DUF1542)
      cl17037
      Location:32 → 563
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      167702299..167715736
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063284187.1 → XP_063140257.1  actin-related protein 5 isoform X2

    2. XM_039105508.2 → XP_038961436.1  actin-related protein 5 isoform X1

      Conserved Domains (1) summary
      cl17037
      Location:2 → 417
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    3. XM_039105510.2 → XP_038961438.1  actin-related protein 5 isoform X3

      Conserved Domains (1) summary
      cl17037
      Location:161 → 288
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    4. XM_039105509.2 → XP_038961437.1  actin-related protein 5 isoform X3

      Conserved Domains (1) summary
      cl17037
      Location:161 → 288
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108600.1: Suppressed sequence

      Description
      NM_001108600.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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