Asic1 acid sensing ion channel subunit 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Asic1provided by RGD
Official Full Name: acid sensing ion channel subunit 1provided by RGD
Primary source: RGD:71062
See related: EnsemblRapid:ENSRNOG00000059765 AllianceGenome:RGD:71062
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Accn2
Summary: Enables inorganic cation transmembrane transporter activity and pH-gated monoatomic ion channel activity. Involved in monoatomic ion transmembrane transport. Acts upstream of or within inorganic cation transmembrane transport. Located in cell surface and membrane. Orthologous to human ASIC1 (acid sensing ion channel subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 56.3), Lung (RPKM 29.5) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q36

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (132677158..132707379)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (130798317..130828535)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (141324714..141354937)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

iMSC exosome delivers hsa-mir-125b-5p and strengthens acidosis resilience through suppression of ASIC1 protein in cerebral ischemia-reperfusion.
Title: iMSC exosome delivers hsa-mir-125b-5p and strengthens acidosis resilience through suppression of ASIC1 protein in cerebral ischemia-reperfusion.
Estrogen protects against acidosis-mediated articular chondrocyte injury by promoting ASIC1a protein degradation.
Title: Estrogen protects against acidosis-mediated articular chondrocyte injury by promoting ASIC1a protein degradation.
DNMT1 involved in the analgesic effect of folic acid on gastric hypersensitivity through downregulating ASIC1 in adult offspring rats with prenatal maternal stress.
Title: DNMT1 involved in the analgesic effect of folic acid on gastric hypersensitivity through downregulating ASIC1 in adult offspring rats with prenatal maternal stress.
Estrogen antagonizes ASIC1a-induced chondrocyte mitochondrial stress in rheumatoid arthritis.
Title: Estrogen antagonizes ASIC1a-induced chondrocyte mitochondrial stress in rheumatoid arthritis.
Acid sensor ASIC1a induces synovial fibroblast proliferation via Wnt/beta-catenin/c-Myc pathway in rheumatoid arthritis.
Title: Acid sensor ASIC1a induces synovial fibroblast proliferation via Wnt/β-catenin/c-Myc pathway in rheumatoid arthritis.
ASIC1a induces mitochondrial apoptotic responses in acute lung injury.
Title: ASIC1a induces mitochondrial apoptotic responses in acute lung injury.
Nesfatin-1 exerts protective effects on acidosis-stimulated chondrocytes and rats with adjuvant-induced arthritis by inhibiting ASIC1a expression.
Title: Nesfatin-1 exerts protective effects on acidosis-stimulated chondrocytes and rats with adjuvant-induced arthritis by inhibiting ASIC1a expression.
Acid-sensitive ion channel 1a mediates osteoarthritis chondrocyte senescence by promoting Lamin B1 degradation.
Title: Acid-sensitive ion channel 1a mediates osteoarthritis chondrocyte senescence by promoting Lamin B1 degradation.
ASIC1a promotes hepatic stellate cell activation through the exosomal miR-301a-3p/BTG1 pathway.
Title: ASIC1a promotes hepatic stellate cell activation through the exosomal miR-301a-3p/BTG1 pathway.
Novel mechanosensory role for acid sensing ion channel subtype 1a in evoking the exercise pressor reflex in rats with heart failure.
Title: Novel mechanosensory role for acid sensing ion channel subtype 1a in evoking the exercise pressor reflex in rats with heart failure.

Submit: New GeneRIF Correction See all GeneRIFs (86)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables inorganic cation transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables ligand-gated sodium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables ligand-gated sodium channel activity	IEA Inferred from Electronic Annotation more info
enables monoatomic cation channel activity	ISO Inferred from Sequence Orthology more info
enables monoatomic ion channel activity	IDA Inferred from Direct Assay more info	PubMed
enables monoatomic ion-gated channel activity	ISO Inferred from Sequence Orthology more info
enables pH-gated monoatomic ion channel activity	IDA Inferred from Direct Assay more info	PubMed
NOT enables pH-gated monoatomic ion channel activity	ISO Inferred from Sequence Orthology more info
enables pH-gated monoatomic ion channel activity	ISO Inferred from Sequence Orthology more info
enables pH-gated monoatomic ion channel activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within associative learning	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within behavioral fear response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in cellular response to pH	ISO Inferred from Sequence Orthology more info
involved_in cellular response to pH	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inorganic cation transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within memory	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within monoatomic cation transport	ISO Inferred from Sequence Orthology more info
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within monoatomic ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of neurotransmitter secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of neurotransmitter secretion	ISO Inferred from Sequence Orthology more info
involved_in protein homotrimerization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of membrane potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynapse assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to acidic pH	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to amphetamine	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of sour taste	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynaptic density membrane	ISO Inferred from Sequence Orthology more info
located_in presynapse	IEA Inferred from Electronic Annotation more info
located_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: acid-sensing ion channel 1

Names: BNaC2; acid-sensing (proton-gated) ion channel 1; amiloride-sensitive cation channel 2, neuronal; brain sodium channel 2; proton gated cation channel ASIC1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001414903.1 → NP_001401832.1 acid-sensing ion channel 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

O88762, P55926, Q91YB8, Q99NA1

UniProtKB/TrEMBL

A0A8L2R026, A6KCG6
NM_024154.3 → NP_077068.1 acid-sensing ion channel 1

See identical proteins and their annotated locations for NP_077068.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

O88762, P55926, Q91YB8, Q99NA1

UniProtKB/TrEMBL

A0A8L2R026, A6KCG6

Conserved Domains (1) summary

TIGR00859
Location:19 → 508

ENaC; sodium channel transporter

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

132677158..132707379

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017595126.3 → XP_017450615.1 acid-sensing ion channel 1 isoform X3

UniProtKB/TrEMBL

A0A8L2R026

Conserved Domains (1) summary

TIGR00859
Location:19 → 509

ENaC; sodium channel transporter
XM_039079937.2 → XP_038935865.1 acid-sensing ion channel 1 isoform X4

Conserved Domains (1) summary

cl02990
Location:1 → 381

ASC; Amiloride-sensitive sodium channel
XM_017595125.3 → XP_017450614.1 acid-sensing ion channel 1 isoform X3

UniProtKB/TrEMBL

A0A8L2R026

Conserved Domains (1) summary

TIGR00859
Location:19 → 509

ENaC; sodium channel transporter
XM_063264284.1 → XP_063120354.1 acid-sensing ion channel 1 isoform X1
XM_006257378.5 → XP_006257440.1 acid-sensing ion channel 1 isoform X2

See identical proteins and their annotated locations for XP_006257440.1

UniProtKB/TrEMBL

A6KCG7

Related

ENSRNOP00000072206.2, ENSRNOT00000077175.3

Conserved Domains (1) summary

cl02990
Location:63 → 541

ASC; Amiloride-sensitive sodium channel
XM_063264285.1 → XP_063120355.1 acid-sensing ion channel 1 isoform X5
XM_063264286.1 → XP_063120356.1 acid-sensing ion channel 1 isoform X6