U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Thy1 Thy-1 cell surface antigen [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24832, updated on 9-Dec-2024

    Summary

    Official Symbol
    Thy1provided by RGD
    Official Full Name
    Thy-1 cell surface antigenprovided by RGD
    Primary source
    RGD:3860
    See related
    EnsemblRapid:ENSRNOG00000006604 AllianceGenome:RGD:3860
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CD7
    Summary
    Enables GPI anchor binding activity; GTPase activator activity; and protein kinase binding activity. Involved in several processes, including T cell receptor signaling pathway; focal adhesion assembly; and positive regulation of release of sequestered calcium ion into cytosol. Acts upstream of or within with a positive effect on cell-cell signaling and negative regulation of neuron projection regeneration. Located in several cellular components, including growth cone; neuron projection membrane; and neuronal cell body membrane. Biomarker of retinal disease and retinal ischemia. Orthologous to human THY1 (Thy-1 cell surface antigen). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 2242.5) and Brain (RPKM 1279.6) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Thy1 in Genome Data Viewer
    Location:
    8q22
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (53286396..53291541)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (44389495..44394688)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (48382121..48387271)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108351689 Neighboring gene uncharacterized LOC134480042 Neighboring gene ubiquitin specific peptidase 2 Neighboring gene membrane frizzled-related protein

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GPI anchor binding PubMed 
    enables GTPase activator activity  
    enables GTPase activator activity PubMed 
    enables enzyme binding PubMed 
    enables integrin binding  
    enables integrin binding  
    enables integrin binding PubMed 
    enables protein binding PubMed 
    enables protein kinase binding PubMed 
    Items 1 - 25 of 44
    Process Evidence Code Pubs
    involved_in T cell receptor signaling pathway PubMed 
    involved_in angiogenesis  
    involved_in angiogenesis  
    involved_in cell adhesion  
    involved_in cell-cell adhesion PubMed 
    acts_upstream_of_or_within_positive_effect cell-cell signaling PubMed 
    involved_in cell-cell signaling  
    involved_in cytoskeleton organization PubMed 
    involved_in focal adhesion assembly PubMed 
    involved_in heterotypic cell-cell adhesion  
    involved_in heterotypic cell-cell adhesion  
    involved_in integrin-mediated signaling pathway  
    involved_in integrin-mediated signaling pathway  
    involved_in integrin-mediated signaling pathway  
    involved_in integrin-mediated signaling pathway PubMed 
    involved_in mast cell activation PubMed 
    involved_in negative regulation of T cell receptor signaling pathway  
    involved_in negative regulation of T cell receptor signaling pathway  
    involved_in negative regulation of apoptotic process PubMed 
    involved_in negative regulation of axonogenesis PubMed 
    involved_in negative regulation of cell migration PubMed 
    involved_in negative regulation of fibroblast proliferation PubMed 
    acts_upstream_of_or_within_positive_effect negative regulation of neuron projection regeneration PubMed 
    involved_in negative regulation of neuron projection regeneration  
    involved_in negative regulation of protein kinase activity PubMed 
    involved_in positive regulation of GTPase activity PubMed 
    involved_in positive regulation of T cell activation PubMed 
    involved_in positive regulation of cellular extravasation  
    involved_in positive regulation of cellular extravasation  
    involved_in positive regulation of focal adhesion assembly  
    involved_in positive regulation of focal adhesion assembly  
    involved_in positive regulation of focal adhesion assembly  
    involved_in positive regulation of focal adhesion assembly PubMed 
    involved_in positive regulation of peptidyl-tyrosine phosphorylation PubMed 
    involved_in positive regulation of release of sequestered calcium ion into cytosol PubMed 
    involved_in protein autophosphorylation PubMed 
    involved_in receptor clustering PubMed 
    involved_in regulation of Rho-dependent protein serine/threonine kinase activity  
    involved_in regulation of Rho-dependent protein serine/threonine kinase activity PubMed 
    involved_in regulation of cell migration  
    involved_in regulation of cell-matrix adhesion  
    involved_in response to axon injury PubMed 
    involved_in retinal cone cell development  
    involved_in retinal cone cell development  
    Items 1 - 25 of 44
    Items 1 - 20 of 27
    Component Evidence Code Pubs
    located_in apical plasma membrane  
    located_in apical plasma membrane  
    located_in axolemma PubMed 
    located_in cell surface PubMed 
    located_in cell surface  
    located_in cell surface  
    located_in cell surface PubMed 
    located_in cytosol PubMed 
    is_active_in dendrite  
    located_in dendrite  
    located_in dendrite membrane PubMed 
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum  
    is_active_in external side of plasma membrane  
    located_in external side of plasma membrane  
    located_in external side of plasma membrane  
    is_active_in glutamatergic synapse  
    located_in growth cone PubMed 
    is_active_in membrane raft  
    located_in membrane raft PubMed 
    located_in membrane raft  
    located_in neuronal cell body membrane PubMed 
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    is_active_in postsynapse  
    is_active_in presynapse  
    located_in side of membrane  
    Items 1 - 20 of 27

    General protein information

    Preferred Names
    thy-1 membrane glycoprotein
    Names
    CD90
    Thy-1 protein
    Thymus cell surface antigen
    thy-1 antigen
    thy-1 glycoprotein
    thymus cell antigen 1, theta
    NP_036805.1
    XP_017450965.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012673.2NP_036805.1  thy-1 membrane glycoprotein preproprotein

      See identical proteins and their annotated locations for NP_036805.1

      Status: VALIDATED

      Source sequence(s)
      CB741211, CB797376, CO561977, X03150
      UniProtKB/Swiss-Prot
      P01830
      UniProtKB/TrEMBL
      A0A8I5ZPP2, A6J3U9, A6J3V0
      Related
      ENSRNOP00000079974.2, ENSRNOT00000095277.2
      Conserved Domains (2) summary
      cd00096
      Location:3340
      Ig; Ig strand B [structural motif]
      cl11960
      Location:24122
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      53286396..53291541
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017595476.2XP_017450965.1  thy-1 membrane glycoprotein isoform X1

      UniProtKB/TrEMBL
      A0A8L2Q3U4
      Related
      ENSRNOP00000008685.2, ENSRNOT00000008685.5
    External link. Please review our privacy policy.