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    Fntb farnesyltransferase, CAAX box, subunit beta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64511, updated on 9-Dec-2024

    Summary

    Official Symbol
    Fntbprovided by RGD
    Official Full Name
    farnesyltransferase, CAAX box, subunit betaprovided by RGD
    Primary source
    RGD:620119
    See related
    EnsemblRapid:ENSRNOG00000071324 AllianceGenome:RGD:620119
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Contributes to peptide binding activity and protein farnesyltransferase activity. Involved in several processes, including positive regulation of cell cycle; positive regulation of cell population proliferation; and positive regulation of nitric-oxide synthase biosynthetic process. Predicted to be part of microtubule associated complex and protein farnesyltransferase complex. Human ortholog(s) of this gene implicated in anxiety disorder. Orthologous to several human genes including FNTB (farnesyltransferase, CAAX box, subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 61.5), Brain (RPKM 50.5) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Fntb in Genome Data Viewer
    Location:
    6q24
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (101269657..101352716)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (95536540..95619587)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (99883959..99966988)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene glutathione peroxidase 2 Neighboring gene RAB15, member RAS oncogene family Neighboring gene MYC associated factor X Neighboring gene ribosomal protein S7, pseudogene 24

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC105303

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables farnesyltranstransferase activity  
    contributes_to peptide binding PubMed 
    enables protein binding PubMed 
    contributes_to protein farnesyltransferase activity  
    contributes_to protein farnesyltransferase activity PubMed 
    enables protein farnesyltransferase activity PubMed 
    enables protein farnesyltransferase activity  
    contributes_to protein farnesyltransferase activity  
    enables protein farnesyltransferase activity  
    enables zinc ion binding  
    enables zinc ion binding  
    enables zinc ion binding  
    Process Evidence Code Pubs
    acts_upstream_of cell population proliferation  
    acts_upstream_of fibroblast proliferation  
    involved_in lipid metabolic process  
    acts_upstream_of_or_within negative regulation of cell population proliferation  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of cell cycle PubMed 
    involved_in positive regulation of cell population proliferation PubMed 
    acts_upstream_of_or_within positive regulation of cell population proliferation  
    acts_upstream_of_or_within positive regulation of fibroblast proliferation  
    involved_in prenylation  
    involved_in protein farnesylation  
    involved_in protein farnesylation  
    acts_upstream_of_or_within regulation of fibroblast proliferation  
    involved_in response to organic cyclic compound PubMed 
    acts_upstream_of_or_within wound healing  
    Component Evidence Code Pubs
    part_of microtubule associated complex  
    part_of microtubule associated complex  
    part_of protein farnesyltransferase complex  
    part_of protein farnesyltransferase complex  
    part_of protein farnesyltransferase complex  
    part_of protein farnesyltransferase complex  

    General protein information

    Preferred Names
    protein farnesyltransferase subunit beta
    Names
    CAAX farnesyltransferase subunit beta
    FTase-beta
    farnesyltransferase beta subunit
    farnesyltransferase, CAAX box, beta
    ras proteins prenyltransferase subunit beta
    NP_742031.1
    XP_038968805.1
    XP_063118516.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172034.2NP_742031.1  protein farnesyltransferase subunit beta

      See identical proteins and their annotated locations for NP_742031.1

      Status: PROVISIONAL

      Source sequence(s)
      BC087675
      UniProtKB/Swiss-Prot
      Q02293
      UniProtKB/TrEMBL
      A6HCB6
      Related
      ENSRNOP00000109911.1, ENSRNOT00000121059.2
      Conserved Domains (1) summary
      cd02893
      Location:75373
      FTase; Protein farnesyltransferase (FTase)_like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). FTases are a subgroup of PTase family of lipid-modifying enzymes. PTases catalyze the ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      101269657..101352716
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039112877.2XP_038968805.1  protein farnesyltransferase subunit beta isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZMQ9
      Related
      ENSRNOP00000079445.1, ENSRNOT00000099844.3
      Conserved Domains (1) summary
      cd02893
      Location:75344
      FTase; Protein farnesyltransferase (FTase)_like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). FTases are a subgroup of PTase family of lipid-modifying enzymes. PTases catalyze the ...
    2. XM_063262446.1XP_063118516.1  protein farnesyltransferase subunit beta isoform X2

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