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    Itga6 integrin subunit alpha 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114517, updated on 9-Dec-2024

    Summary

    Official Symbol
    Itga6provided by RGD
    Official Full Name
    integrin subunit alpha 6provided by RGD
    Primary source
    RGD:621633
    See related
    EnsemblRapid:ENSRNOG00000001518 AllianceGenome:RGD:621633
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables laminin binding activity. Involved in cell-cell adhesion; cellular response to organic cyclic compound; and positive regulation of cell-substrate adhesion. Located in adherens junction and filopodium. Part of integrin alpha6-beta4 complex. Human ortholog(s) of this gene implicated in junctional epidermolysis bullosa and junctional epidermolysis bullosa with pyloric atresia. Orthologous to human ITGA6 (integrin subunit alpha 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 465.0), Thymus (RPKM 310.7) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Itga6 in Genome Data Viewer
    Location:
    3q23
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (77012168..77097076)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (56604512..56689428)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (58442904..58515124)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103691816 Neighboring gene mitochondrial ribosomal protein S36, pseudogene 2 Neighboring gene pyruvate dehydrogenase kinase 1 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene Rap guanine nucleotide exchange factor 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables insulin-like growth factor I binding  
    enables integrin binding  
    enables laminin binding PubMed 
    enables neuregulin binding  
    enables protein-containing complex binding PubMed 
    Items 1 - 25 of 27
    Process Evidence Code Pubs
    acts_upstream_of_or_within brown fat cell differentiation  
    involved_in cell adhesion mediated by integrin  
    involved_in cell-cell adhesion  
    involved_in cell-cell adhesion PubMed 
    involved_in cell-matrix adhesion  
    acts_upstream_of_or_within cell-matrix adhesion  
    involved_in cell-matrix adhesion  
    involved_in cell-substrate adhesion  
    involved_in cellular response to organic cyclic compound PubMed 
    involved_in ectodermal cell differentiation  
    acts_upstream_of_or_within filopodium assembly  
    involved_in integrin-mediated signaling pathway  
    involved_in leukocyte migration  
    acts_upstream_of_or_within leukocyte migration  
    acts_upstream_of_or_within lymphoid lineage cell migration  
    involved_in nail development  
    involved_in negative regulation of extrinsic apoptotic signaling pathway  
    acts_upstream_of_or_within odontogenesis of dentin-containing tooth  
    involved_in positive regulation of GTPase activity  
    acts_upstream_of_or_within positive regulation of apoptotic process  
    involved_in positive regulation of cell migration  
    acts_upstream_of_or_within positive regulation of cell-cell adhesion  
    involved_in positive regulation of cell-substrate adhesion PubMed 
    involved_in positive regulation of neuron projection development  
    involved_in positive regulation of phosphorylation  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in skin morphogenesis  
    Items 1 - 25 of 27
    Component Evidence Code Pubs
    located_in adherens junction PubMed 
    located_in basal part of cell  
    located_in basal plasma membrane  
    located_in basement membrane  
    located_in basolateral plasma membrane  
    located_in cell surface  
    is_active_in external side of plasma membrane  
    located_in external side of plasma membrane  
    located_in filopodium PubMed 
    located_in hemidesmosome  
    part_of integrin alpha6-beta1 complex  
    part_of integrin alpha6-beta4 complex PubMed 
    part_of integrin complex  
    part_of integrin complex  
    located_in plasma membrane  

    General protein information

    Preferred Names
    integrin alpha-6
    Names
    integrin, alpha 6

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053725.2NP_446177.2  integrin alpha-6 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6G9S4, A6HM56, G3V667
      Related
      ENSRNOP00000002075.4, ENSRNOT00000002075.6
      Conserved Domains (3) summary
      smart00191
      Location:374425
      Int_alpha; Integrin alpha (beta-propellor repeats)
      pfam00357
      Location:10381052
      Integrin_alpha; Integrin alpha cytoplasmic region
      pfam08441
      Location:464939
      Integrin_alpha2; Integrin alpha

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      77012168..77097076
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063282995.1XP_063139065.1  integrin alpha-6 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AJE9, A0A8I6G9S4
      Related
      ENSRNOP00000111703.1, ENSRNOT00000157671.1
    2. XM_039104096.2XP_038960024.1  integrin alpha-6 isoform X1

      UniProtKB/TrEMBL
      A0A8I6G9S4, A6HM55
      Conserved Domains (2) summary
      smart00191
      Location:374425
      Int_alpha; Integrin alpha (beta-propellor repeats)
      pfam08441
      Location:464939
      Integrin_alpha2; Integrin alpha
    3. XM_039104095.2XP_038960023.1  integrin alpha-6 isoform X1

      UniProtKB/TrEMBL
      A0A8I6G9S4, A6HM55
      Conserved Domains (2) summary
      smart00191
      Location:374425
      Int_alpha; Integrin alpha (beta-propellor repeats)
      pfam08441
      Location:464939
      Integrin_alpha2; Integrin alpha
    4. XM_039104097.2XP_038960025.1  integrin alpha-6 isoform X2

      UniProtKB/TrEMBL
      A0A8I6G9S4, A6HM56, G3V667
      Conserved Domains (3) summary
      smart00191
      Location:374425
      Int_alpha; Integrin alpha (beta-propellor repeats)
      pfam00357
      Location:10381052
      Integrin_alpha; Integrin alpha cytoplasmic region
      pfam08441
      Location:464939
      Integrin_alpha2; Integrin alpha
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