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    Cfap20 cilia and flagella associated protein 20 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307642, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cfap20provided by RGD
    Official Full Name
    cilia and flagella associated protein 20provided by RGD
    Primary source
    RGD:1308493
    See related
    EnsemblRapid:ENSRNOG00000042179 AllianceGenome:RGD:1308493
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gtl3
    Summary
    Predicted to be involved in several processes, including positive regulation of feeding behavior; protein polyglutamylation; and regulation of cilium beat frequency involved in ciliary motility. Predicted to be located in axonemal microtubule; centriole; and nucleoplasm. Predicted to be active in axonemal B tubule inner sheath; ciliary basal body; and sperm flagellum. Orthologous to human CFAP20 (cilia and flagella associated protein 20). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 280.6), Lung (RPKM 179.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cfap20 in Genome Data Viewer
    Location:
    19p13
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (9614265..9628612)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (9608867..9622558)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (10024938..10038838)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 113 Neighboring gene casein kinase 2 alpha 2 Neighboring gene matrix metallopeptidase 15 Neighboring gene U6 snRNA biogenesis phosphodiesterase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Bug22p, a conserved centrosomal/ciliary protein also present in higher plants, is required for an effective ciliary stroke in Paramecium. Laligné C, et al. Eukaryot Cell, 2010 Apr. PMID 20118210, Free PMC Article
    2. Bug22 influences cilium morphology and the post-translational modification of ciliary microtubules. Mendes Maia T, et al. Biol Open, 2014 Feb 15. PMID 24414207, Free PMC Article
    3. Proteomic analysis of mammalian primary cilia. Ishikawa H, et al. Curr Biol, 2012 Mar 6. PMID 22326026, Free PMC Article
    4. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    5. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124689

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cilium assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in flagellated sperm motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in flagellated sperm motility ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell motility IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell motility ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of feeding behavior IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of feeding behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of feeding behavior ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein polyglutamylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein polyglutamylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of cilium beat frequency involved in ciliary motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cilium beat frequency involved in ciliary motility IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cilium beat frequency involved in ciliary motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cilium beat frequency involved in ciliary motility ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axonemal B tubule inner sheath ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axonemal microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in axonemal microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axonemal microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in centriole IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centriole ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in ciliary basal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ciliary basal body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ciliary basal body ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in motile cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in sperm flagellum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in sperm flagellum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    cilia- and flagella-associated protein 20
    Names
    UPF0468 protein C16orf80 homolog
    gene trap locus 3 protein homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037978.2 → NP_001033067.1  cilia- and flagella-associated protein 20 isoform 2

      See identical proteins and their annotated locations for NP_001033067.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/Swiss-Prot
      Q499T7
      UniProtKB/TrEMBL
      A0A8I5ZUW3
      Conserved Domains (1) summary
      pfam05018
      Location:6 → 144
      DUF667; Protein of unknown function (DUF667)

    2. NM_001399181.1 → NP_001386110.1  cilia- and flagella-associated protein 20 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A0A0H2UI05, A0A8I5ZUW3, A6JY06
      Related
      ENSRNOP00000058109.4, ENSRNOT00000061392.6
      Conserved Domains (1) summary
      pfam05018
      Location:1 → 185
      DUF667; Protein of unknown function (DUF667)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      9614265..9628612
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039097696.2 → XP_038953624.1  cilia- and flagella-associated protein 20 isoform X1

      Conserved Domains (1) summary
      pfam05018
      Location:1 → 185
      DUF667; Protein of unknown function (DUF667)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q499T7.1 GenPept UniProtKB/Swiss-Prot:Q499T7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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