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    Plpp7 phospholipid phosphatase 7 (inactive) [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296635, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Plpp7provided by RGD
    Official Full Name
    phospholipid phosphatase 7 (inactive)provided by RGD
    Primary source
    RGD:1305821
    See related
    EnsemblRapid:ENSRNOG00000010068 AllianceGenome:RGD:1305821
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ppapdc3; RGD1305821
    Summary
    Predicted to enable sphingosine-1-phosphate phosphatase activity. Predicted to act upstream of or within negative regulation of myotube differentiation. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in membrane and nuclear envelope. Orthologous to human PLPP7 (phospholipid phosphatase 7 (inactive)). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 556.9), Heart (RPKM 157.4) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Plpp7 in Genome Data Viewer
    Location:
    3p12
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (35782215..35796577)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (15384461..15398820)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (11114551..11130427)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 78, member A Neighboring gene uncharacterized LOC134486353 Neighboring gene uncharacterized LOC120101521 Neighboring gene proline-rich coiled-coil 2B Neighboring gene small nucleolar RNA, C/D box 62A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Regulation of myoblast differentiation by the nuclear envelope protein NET39. Liu GH, et al. Mol Cell Biol, 2009 Nov. PMID 19704009, Free PMC Article
    2. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109271

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    NOT enables lipid phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sphingosine-1-phosphate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of myotube differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    inactive phospholipid phosphatase 7
    Names
    phosphatidic acid phosphatase type 2 domain containing 3
    phosphatidic acid phosphatase type 2 domain-containing protein 3
    probable lipid phosphate phosphatase PPAPDC3
    NP_001012349.1
    XP_038960681.1
    XP_063139561.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012349.2 → NP_001012349.1  inactive phospholipid phosphatase 7

      See identical proteins and their annotated locations for NP_001012349.1

      Status: VALIDATED

      Source sequence(s)
      AA900756, BC089948, CB771354
      UniProtKB/Swiss-Prot
      Q5FVJ3
      UniProtKB/TrEMBL
      A6JU41
      Related
      ENSRNOP00000013507.4, ENSRNOT00000013507.6
      Conserved Domains (2) summary
      COG0671
      Location:123 → 249
      PgpB; Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]
      cd03391
      Location:97 → 255
      PAP2_containing_2_like; PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to eukaryota, lacks functional characterization and may act as a ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      35782215..35796577
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104753.2 → XP_038960681.1  inactive phospholipid phosphatase 7 isoform X1

      Conserved Domains (1) summary
      cd03391
      Location:39 → 143
      PAP2_containing_2_like; PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to eukaryota, lacks functional characterization and may act as a ...

    2. XM_063283491.1 → XP_063139561.1  inactive phospholipid phosphatase 7 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AEA9
      Related
      ENSRNOP00000090722.1, ENSRNOT00000099438.2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5FVJ3.1 GenPept UniProtKB/Swiss-Prot:Q5FVJ3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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