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    Slc46a1 solute carrier family 46 member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303333, updated on 9-Dec-2024

    Summary

    Official Symbol
    Slc46a1provided by RGD
    Official Full Name
    solute carrier family 46 member 1provided by RGD
    Primary source
    RGD:1309472
    See related
    EnsemblRapid:ENSRNOG00000010291 AllianceGenome:RGD:1309472
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    rPCFT; RGD1309472
    Summary
    Predicted to enable folic acid:proton symporter activity; heme transmembrane transporter activity; and methotrexate transmembrane transporter activity. Predicted to be involved in folate import across plasma membrane; heme transport; and proton transmembrane transport. Located in brush border membrane. Biomarker of chronic kidney disease. Human ortholog(s) of this gene implicated in hereditary folate malabsorption. Orthologous to human SLC46A1 (solute carrier family 46 member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 76.2), Brain (RPKM 31.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Slc46a1 in Genome Data Viewer
    Location:
    10q25
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (63859551..63865987)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (63361504..63367940)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (65728508..65741708)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S2, pseudogene 18 Neighboring gene solute carrier family 13 member 2 Neighboring gene sterile alpha and TIR motif containing 1 Neighboring gene vitronectin

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Clone Names

    • MGC108986

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables folic acid binding  
    enables folic acid transmembrane transporter activity  
    enables folic acid transmembrane transporter activity  
    enables folic acid:proton symporter activity  
    NOT enables heme transmembrane transporter activity  
    enables heme transmembrane transporter activity  
    enables heme transmembrane transporter activity  
    enables methotrexate transmembrane transporter activity  
    enables methotrexate transmembrane transporter activity  
    enables proton transmembrane transporter activity  
    enables symporter activity  
    enables symporter activity  
    enables transmembrane transporter activity  
    Process Evidence Code Pubs
    involved_in folate import across plasma membrane  
    involved_in folate transmembrane transport  
    involved_in folic acid transport  
    involved_in folic acid transport  
    involved_in heme transport  
    involved_in heme transport  
    involved_in methotrexate transport  
    involved_in proton transmembrane transport  
    involved_in transmembrane transport  
    Component Evidence Code Pubs
    located_in apical plasma membrane  
    located_in apical plasma membrane  
    is_active_in basolateral plasma membrane  
    located_in basolateral plasma membrane  
    is_active_in basolateral plasma membrane  
    located_in brush border membrane PubMed 
    located_in cytoplasm  
    located_in cytoplasm  
    located_in endosome  
    located_in endosome  
    located_in endosome membrane  
    is_active_in plasma membrane  
    is_active_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    proton-coupled folate transporter
    Names
    PCFT/HCP1
    heme carrier protein 1
    solute carrier family 46 (folate transporter), member 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013969.1NP_001013991.1  proton-coupled folate transporter

      See identical proteins and their annotated locations for NP_001013991.1

      Status: PROVISIONAL

      Source sequence(s)
      BC089868
      UniProtKB/Swiss-Prot
      Q5EBA8
      UniProtKB/TrEMBL
      A6HH50
      Related
      ENSRNOP00000013698.4, ENSRNOT00000013698.9
      Conserved Domains (1) summary
      cl28910
      Location:22444
      MFS; Major Facilitator Superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      63859551..63865987
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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