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    Mpv17l MPV17 mitochondrial inner membrane protein like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100362572, updated on 9-Dec-2024

    Summary

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    Symbol
    Mpv17lprovided by RGD
    Full Name
    MPV17 mitochondrial inner membrane protein likeprovided by RGD
    Primary source
    RGD:2324483
    See related
    EnsemblRapid:ENSRNOG00000003285 AllianceGenome:RGD:2324483
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in negative regulation of hydrogen peroxide biosynthetic process; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; and reactive oxygen species metabolic process. Predicted to be located in peroxisome. Predicted to be active in mitochondrion. Orthologous to human MPV17L (MPV17 mitochondrial inner membrane protein like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 368.7), Liver (RPKM 85.9) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mpv17l in Genome Data Viewer
    Location:
    10q11
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (2495605..2532448, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (1988451..2025300, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (3321488..3359219)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene large ribosomal subunit protein uL13-like Neighboring gene bMERB domain containing 1 Neighboring gene nuclear receptor coactivator 4, pseudogene 1 Neighboring gene pyridoxal-dependent decarboxylase domain containing 1 Neighboring gene uncharacterized LOC102552514 Neighboring gene N-terminal asparagine amidase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Human Mpv17-like protein is localized in peroxisomes and regulates expression of antioxidant enzymes. Iida R, et al. Biochem Biophys Res Commun, 2006 Jun 9. PMID 16631601
    2. Identification of Rhit as a novel transcriptional repressor of human Mpv17-like protein with a mitigating effect on mitochondrial dysfunction, and its transcriptional regulation by FOXD3 and GABP. Iida R, et al. Free Radic Biol Med, 2012 Apr 15. PMID 22306510
    3. A proteome-wide perspective on peroxisome targeting signal 1(PTS1)-Pex5p affinities. Ghosh D, et al. J Am Chem Soc, 2010 Mar 24. PMID 20178365
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in mitochondrial ribosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of hydrogen peroxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mpv17-like protein
    Names
    MPV17 mitochondrial membrane protein-like
    Mpv17 transgene, kidney disease mutant-like (predicted)-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001402078.1 → NP_001389007.1  mpv17-like protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A6K4F3

    2. NM_001402079.1 → NP_001389008.1  mpv17-like protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      2495605..2532448 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008767468.4 → XP_008765690.1  mpv17-like protein isoform X3

      See identical proteins and their annotated locations for XP_008765690.1

      Related
      ENSRNOP00000095618.2, ENSRNOT00000117447.2
      Conserved Domains (1) summary
      pfam04117
      Location:9 → 68
      Mpv17_PMP22; Mpv17 / PMP22 family

    2. XM_063268245.1 → XP_063124315.1  mpv17-like protein isoform X6

    3. XM_008767467.4 → XP_008765689.1  mpv17-like protein isoform X1

      See identical proteins and their annotated locations for XP_008765689.1

      UniProtKB/TrEMBL
      A6K4F2
      Related
      ENSRNOP00000094538.2, ENSRNOT00000115587.2
      Conserved Domains (1) summary
      pfam04117
      Location:107 → 156
      Mpv17_PMP22; Mpv17 / PMP22 family

    4. XM_063268244.1 → XP_063124314.1  mpv17-like protein isoform X5

    5. XM_008767469.3 → XP_008765691.1  mpv17-like protein isoform X4

      See identical proteins and their annotated locations for XP_008765691.1

      Conserved Domains (1) summary
      pfam04117
      Location:3 → 62
      Mpv17_PMP22; Mpv17 / PMP22 family

    6. XM_063268243.1 → XP_063124313.1  mpv17-like protein isoform X2

      UniProtKB/TrEMBL
      A6K4F4

    RNA

    1. XR_010055116.1 RNA Sequence

    2. XR_010055114.1 RNA Sequence

    3. XR_010055115.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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